| Santiago Guarderas | |
| Office: | Metropolitan Mayor of Quito |
| Term Start: | 30 September 2021 |
| Term End: | 14 May 2023 |
| Predecessor: | Jorge Yunda |
| Successor: | Pabel Muñoz |
| Office1: | Vice Metropolitan Mayor of Quito |
| Term Start1: | 14 May 2019 |
| Term End1: | 29 September 2021 |
| Predecessor1: | Eduardo del Pozo |
| Successor1: | Brith Vaca |
| Office2: | Member of the National Congress from the Pichincha Province |
| Term Start2: | 5 January 2007 |
| Term End2: | 30 November 2007 |
| Birth Name: | Santiago Guarderas Izquierdo |
| Birth Place: | Quito, Ecuador |
| Education: | Pontifical Catholic University of Ecuador |
| Party: | Ecuadorian Union Party |
| Otherparty: | Democratic Left Social Christian Party |
| Occupation: | Lawyer and politician |
Santiago Guarderas Izquierdo (born 1964) is an Ecuadorian politician and lawyer. He was the Metropolitan Mayor of Quito from 30 September 2021 to 14 May 2023.
Born in 1964, he studied law at Pontifical Catholic University of Ecuador in Quito. He worked on the faculty at the same institution.
Guarderas was elected to the National Congress in January 2007 as a member of the Social Christian Party. He left office when the assembly was dissolved in November 2007. He unsuccessfully ran for the National Assembly in 2017.
In 2019, he became Vice Mayor of Quito alongside Jorge Yunda as Mayor. In July 2021, he assumed the role of mayor when there was a leadership dispute with Yunda during protests.[1]
On 30 September 2021, Guarderas succeeded Yunda as Quito's mayor. He was succeeded by Pabel Muñoz on 14 May 2023.[2]