| Santiago-Comaina Reserved Zone | |
| Location: | Peru, Amazonas Region, Condorcanqui Province |
| Area: | 863,277 ha, expanded to 1,642,570 ha in 2000 |
| Established: | January 21, 1999 (D.S. Nº 005-99-AG) |
The Santiago-Comaina Reserved Zone (Spanish; Castilian: Reserva Comunal Santiago-Comaina) is a protected area in Peru located in the Amazonas Region, Condorcanqui Province.