| Santander de Quilichao | |
| Nickname: | City of the Samanes |
| Settlement Type: | City |
| Mapsize: | 250px |
| Pushpin Map: | Colombia |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Name: |  Colombia |
| Subdivision Type1: | Department |
| Subdivision Name1: | Cauca Department |
| Leader Title: | Mayor |
| Leader Name: | Luís Eduardo Grijalba |
| Established Title: | Founded |
| Established Date: | July 16, 1543 |
| Area Total Km2: | 518.2 |
| Area Urban Km2: | 10.880 |
| Population As Of: | 2023 |
| Population Footnotes: | [1] |
| Population Total: | 220,000 |
| Population Density Km2: | auto |
| Population Metro: | 180,000 |
| Population Urban: | 180,000 |
| Population Density Urban Km2: | auto |
| Population Demonym: | Quilichagüeño |
| Coordinates: | 3.0131°N -76.32°W |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
| Elevation M: | 1071 |
| Area Code: | 57 + 2 |
| Blank Name: | Climate |
| Blank Info: | Af |
| Website: | Official website |
Santander de Quilichao is a city in the north of the Cauca Department, Colombia at 97 km to the north of Popayán and 45 km to the south of Cali.