The ship had a very short life, and her most notable action was during the Battle of the Downs, on 21 October 1639, where Santa Teresa was commanded by Admiral Lope de Hoces. Santa Teresa was burned by a fire ship, and Admiral Lope de Hoces died.
The galleon was built by Bento Francisco in Porto, and launched in 1637. It was armed with 60 guns, and it had 1,200 tons burthen. It is classified in some contemporaneous documents as a galleon, and as a carrack in others. The galleon was built with wood from Minho, about which, writing the General, D. Lope de Hoces to the King Philip IV, told him: "Were worthy of being guarded, like the Cerro de Potosí itself, those mountains in Portugal, where such wood was created."
Bore comparison with her more famous contemporaries, the English HMS Sovereign of the Seas and the French Couronne, and in sea-going qualities probably surpassed both of them.
All contemporary accounts of the battle emphasize her strength and beauty; and her destruction by a Dutch fire ship forms the central theme of all contemporary paintings, prints and drawings relating to this famous action.