| Santa Sylvina | |
| Native Name Lang: | es |
| Settlement Type: | Town |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of Santa Sylvina in Argentina |
| Coordinates: | -27.7833°N -70°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Chaco |
| Subdivision Type2: | Department |
| Subdivision Name2: | Fray Justo Santa María del Oro |
| Unit Pref: | Metric |
| Elevation M: | 61 |
| Population Total: | 9040 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | H3541 |
| Area Code Type: | Dialing code |
| Area Code: | +54 3735 |
Santa Sylvina is a town in Chaco Province, Argentina. It is the head town of the Fray Justo Santa María del Oro Department. The town was established in 1944.