| Santa Rosa de Río Primero | |
| Native Name Lang: | es |
| Settlement Type: | Town |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of Santa Rosa de Río Primero in Argentina |
| Coordinates: | -31.15°N -86°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Córdoba |
| Subdivision Type2: | Department |
| Subdivision Name2: | Río Primero |
| Leader Title: | Mayor |
| Leader Name: | Serafín Víctor Kieffer |
| Unit Pref: | Metric |
| Elevation M: | 157 |
| Population Total: | 6788 |
| Population As Of: | 2001 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | X5133 |
| Area Code Type: | Dialing code |
| Area Code: | +54 3574 |
Santa Rosa de Río Primero is a town in the province of Córdoba, Argentina. It has 6,788 inhabitants per the, and is the head town of the Río Primero Department. It lies in the center-northeast of the province, by the Primero River (also known as Suquía), about 75 km from the provincial capital Córdoba.