| Santa Rosa River | |
| Pushpin Map: | Brazil |
| River System: | Purus River |
| Mouth Location: | Purus River, Santa Rosa do Purus |
| Mouth Coordinates: | -9.4286°N -70.4951°W |
| Subdivision Type1: | Country |
| Subdivision Name1: | Peru, Brazil |
Santa Rosa River is a river of Acre state in western Brazil, a tributary of the Purus River.
The river defines the boundary between Peru and Brazil in the centre of the state of Acre, then runs for a short distance along the boundary of the Santa Rosa do Purus National Forest, a sustainable use conservation unit created in 2001, until it joins the Purus River opposite the community of Santa Rosa do Purus.