| Santa Rosa | |
| Native Name: | Departamento Santa Rosa |
| Settlement Type: | Department |
| Coordinates: | -33.2833°N -70°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Established Date: | April 17, 1874 |
| Founder: | ? |
| Seat Type: | Seat |
| Seat: | Santa Rosa |
| Leader Title: | Mayor |
| Leader Name: | Flor Destéfanis, PJ |
| Unit Pref: | Metric |
| Area Total Km2: | 8,510 |
| Population Total: | 15,818 |
| Population Density Km2: | auto |
| Population Demonym: | santaroseño/a |
| Postal Code Type: | Postal Code |
| Postal Code: | M5596 |
| Postal2 Code Type: | IFAM |
| Postal2 Code: | MZA016 |
| Area Code Type: | Area Code |
| Area Code: | 02623 |
| Blank Name Sec1: | Patron saint |
| Blank Info Sec1: | ? |
| Website: | no |
Santa Rosa is a department located in the centre of Mendoza Province in Argentina.
The provincial subdivision has a population of about 16,000 inhabitants in an area of, and its capital city is Santa Rosa, which is located around from the Federal Capital.