| Santa Maria degli Angeli | |
| Settlement Type: | Frazione |
| Pushpin Map: | Italy |
| Coordinates: | 43.0589°N 12.5781°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Italy |
| Subdivision Type1: | Region |
| Subdivision Name1: | Umbria |
| Subdivision Type2: | Province |
| Subdivision Name2: | Perugia |
| Subdivision Type3: | Italian: [[Comune]] |
| Subdivision Name3: | Assisi |
| Elevation Footnotes: | [1] |
| Elevation M: | 218 |
| Population Total: | 6665 |
| Population As Of: | 2001 |
| Population Demonym: | Angelani |
| Timezone1: | CET |
| Utc Offset1: | +1 |
| Timezone1 Dst: | CEST |
| Utc Offset1 Dst: | +2 |
| Postal Code Type: | Postcode |
| Postal Code: | 06081 |
| Area Code: | 075 |
Santa Maria degli Angeli is a frazione of the comune of Assisi in the Province of Perugia, Umbria, central Italy. It stands at an elevation of 218 metres above sea level. At the time of the Istat census of 2001 it had 6,665 inhabitants, and is located c. 4 km south from Assisi. The name of the city was used by the Spanish Franciscan missionaries as the name of Los Angeles, currently one of the largest cities of the United States.
It is home to the Basilica of Santa Maria degli Angeli, which includes the Porziuncola, the most sacred place of the various Franciscan Orders. St. Francis of Assisi himself died here.