| Santa María de Punilla | |
| Native Name Lang: | es |
| Settlement Type: | Town |
| Pushpin Map: | Argentina |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Subdivision Type1: | Province |
| Subdivision Name1: | Córdoba |
| Subdivision Type2: | Department |
| Subdivision Name2: | Punilla |
| Established Title: | Foundation |
| Established Date: | June 25, 1585 |
| Leader Party: | UCR |
| Leader Title: | Mayor |
| Leader Name: | Dart Zanotti |
| Unit Pref: | Metric |
| Elevation M: | 654 |
| Population Total: | 9,526 |
| Population As Of: | 2010 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | X5164 |
| Area Code Type: | Dialing code |
| Area Code: | 03541 |
Santa Maria de Punilla is a town in the Punilla Department in the province of Córdoba, Argentina. The town has a population of 9,526 inhabitants (INDEC, 2010) and is located on National Route 38, and the Tren de las Sierras line of the General Manuel Belgrano Railway. The center of Santa Maria de Punilla is located approximately 50 km northwest of the state's capital city of Córdoba and 3 km south of the city of, Cosquín.
The municipality is also located on the banks of the Cosquín River. Originally, the area belonged to an indigenous Comechingón community known as "Toaén", encompassing what is now Santa Maria, Cosquín, Bialet Massé and neighboring areas.