| Santa Maria River | |
| Source1 Location: | Rio Grande do Sul state |
| Mouth Location: | Ibicuí River |
| Subdivision Type1: | Country |
| Subdivision Name1: | Brazil |
The Santa Maria River (Portuguese, Rio Santa Maria) is a river of Rio Grande do Sul state in southern Brazil. It joins the Ibicuí-Mirim River to form the Ibicuí River.