| Santa María | |
| Native Name: | Departamento Santa María |
| Settlement Type: | Department |
| Coordinates: | -26.6833°N -68°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Established Date: | ? |
| Founder: | ? |
| Seat Type: | Seat |
| Seat: | Santa María |
| Leader Title: | Mayor |
| Leader Name: | Julio Hilario Lagoria, FCS |
| Unit Pref: | Metric |
| Area Total Km2: | 5,740 |
| Population Total: | 22,127 |
| Population Density Km2: | auto |
| Population Demonym: | ? |
| Postal Code Type: | Postal Code |
| Postal Code: | K4139 |
| Postal2 Code Type: | IFAM |
| Postal2 Code: | CAT028 |
| Area Code Type: | Area Code |
| Area Code: | 03838 |
| Blank Name Sec1: | Patron saint |
| Blank Info Sec1: | ? |
Santa María is a north eastern department of Catamarca Province in Argentina.
The provincial subdivision has a population of about 22,000 inhabitants in an area of, and its capital city is Santa María.