| Official Name: | Santa Margarida |
| Pushpin Map: | Sao Tome |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location on São Tomé Island |
| Subdivision Type: | Country |
| Subdivision Name: | São Tomé and Príncipe |
| Subdivision Type1: | Island |
| Subdivision Name1: | São Tomé |
| Subdivision Type2: | District |
| Subdivision Name2: | Mé-Zóchi |
| Population As Of: | 2012 |
| Population Total: | 384 |
| Population Density Km2: | auto |
| Timezone: | WAT |
| Utc Offset: | +1 |
| Coordinates: | 0.3245°N 6.6587°W |
Santa Margarida is a village in the mid-north of São Tomé Island in São Tomé and Príncipe, part of the Mé-Zóchi District. Its population is 384 (2012 census).[1] It lies 1 km southwest of Madalena and 4 km northwest of Trindade.