| Type: | commune |
| County: | Botoșani |
| Official Name: | Santa Mare |
| Subdivisions: | Santa Mare, Bădărăi, Berza, Bogdănești, Durnești, Ilișeni, Rânghilești, Rânghilești-Deal |
| Leader Name: | Cristian Anton |
| Leader Party: | PSD |
| Leader Term: | 2024 - 2028 |
| Coordinates: | 47.6°N 48°W |
| Area Total Km2: | 61.36 |
| Population Total: | auto |
| Postal Code: | 717345 |
| Area Code: | +40 x31 |
Santa Mare is a commune in Botoșani County, Western Moldavia, Romania. It is composed of eight villages: Bădărăi, Berza, Bogdănești, Durnești, Ilișeni, Rânghilești, Rânghilești-Deal and Santa Mare.