| Official Name: | Santa María de la Isla, Spain |
| Subdivision Name3: | Santa María de la Isla |
| Area Total Km2: | 12.75 |
| Elevation M: | 788 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
| Website: | http://www.santamariadelaisla.com |
Santa María de la Isla is a municipality located in the province of León, Castile and León, Spain. According to the 2004 census (INE), the municipality had a population of 639 inhabitants.