| Santa María District | |
| Mapsize: | 300px |
| Pushpin Map: | Panama |
| Pushpin Label Position: | right |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location of the district capital in Panama |
| Subdivision Type: | Country |
| Subdivision Name: |  Panama |
| Subdivision Type1: | Province |
| Subdivision Name1: | Herrera Province |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Santa María |
| Unit Pref: | Imperial |
| Area Total Km2: | 158 |
| Population As Of: | 2000 |
| Population Total: | 6,992 |
| Population Blank1 Title: | Ethnicities |
| Timezone: | ETZ |
| Utc Offset: | -5 |
| Coordinates: | 8.1167°N -120°W |
Santa María District is a district (distrito) of Herrera Province in Panama. The population according to the 2000 census was 6,992.[1] The district covers a total area of 158 km2. The capital lies at the city of Santa María.[1]
Santa María District is divided administratively into the following corregimientos: