| Santa María Department | |
| Native Name: | Departamento Santa María |
| Native Name Lang: | es |
| Settlement Type: | Department |
| Mapsize: | frameless |
| Coordinates: | -31.65°N -89°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Established Title: | Foundation |
| Seat Type: | Capital |
| Seat: | Alta Gracia |
| Unit Pref: | Metric |
| Area Total Km2: | 3427 |
| Population Total: | 86083 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Pop. change |
| Population Blank1: | +7.63% |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | Postal code |
| Postal Code: | X5186 |
| Area Code Type: | Dialing code |
| Area Code: | 03547 |
| Blank Name Sec1: | Distances to |
| Blank Info Sec1: | |
| Blank1 Info Sec1: | 747km (464miles) |
| Blank2 Name Sec1: | Córdoba |
| Blank2 Info Sec1: | 39km (24miles) |
Santa María Department is a department of Córdoba Province in Argentina.
The provincial subdivision has a population of about 86,083 inhabitants in an area of 3,427 km2, and its capital city is Alta Gracia, which is located around 747 km from the Capital federal.
The Jesuit Block and Estancias of Córdoba World Heritage Site is located in Alta Gracia.