| Santa María | |
| Native Name Lang: | es |
| Settlement Type: | City |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of Santa María in Argentina |
| Coordinates: | -26.6833°N -68°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | Santa María |
| Unit Pref: | Metric |
| Population Total: | 17030 |
| Population As Of: | 2010 census |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | K4139 |
| Area Code Type: | Dialing code |
| Area Code: | +54 3838 |
Santa María is a city in the province of Catamarca, Argentina. It has about 17,030 inhabitants per the, and is the head town of the department of the same name.
Santa María has a cool arid climate (Köppen BWk). Summers feature hot afternoons, cool to pleasant mornings, and occasional rainfall from thunderstorms, whilst winters feature chilly to freezing mornings, warm afternoons, and essentially no precipitation.