| Santa Lucía | |
| Native Name: | Departamento Santa Lucía |
| Settlement Type: | Department |
| Coordinates: | -31.5333°N -96°W |
| Subdivision Type: | Country |
| Subdivision Name: | Argentina |
| Established Title: | Established |
| Established Date: | December 4, 1942 |
| Founder: | ? |
| Seat Type: | Seat |
| Seat: | Santa Lucía |
| Leader Title: | Mayor |
| Leader Name: | Marcelo Orrego (2011-present) |
| Unit Pref: | Metric |
| Area Total Km2: | 45 |
| Population Total: | 43565 |
| Population Density Km2: | auto |
| Population Demonym: | lucianesco/a |
| Postal Code Type: | Postal Code |
| Postal Code: | 5400 |
| Postal2 Code Type: | IFAM |
| Postal2 Code: | SJU014 |
| Area Code Type: | Area Code |
| Area Code: | 0264 |
| Blank Name Sec1: | Patron saint |
| Blank Info Sec1: | Santa Lucía |
Santa Lucía is a central department of San Juan Province in Argentina.
The provincial subdivision has a population of about 43.565 inhabitants in an area of, and its capital city is Santa Lucía, which is located around from Capital Federal.