| Santa Isabel do Rio Negro | |
| Settlement Type: | Municipality |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Location in Brazil |
| Subdivision Type: | Country |
| Subdivision Name: |  Brazil |
| Subdivision Name1: | North |
| Subdivision Name2: | Amazonas |
| Area Total Km2: | 62846 |
| Population As Of: | 2020 |
| Population Total: | 25,865 |
| Population Density Km2: | 0.29 |
| Timezone: | AMT |
| Utc Offset: | -4 |
| Coordinates: | -0.4139°N -65.0189°W |
Santa Isabel do Rio Negro (Saint Isabel of Black River) is a municipality located in the Brazilian state of Amazonas. Its population was 25,865 (2020)[1] and its area is .[2] Pico da Neblina, the highest mountain in Brazil at 2,994 metres (9,822 feet), is located in the municipality. The Municipality was formerly called Tapuruquara.
Pico da Neblina, the highest mountain in Brazil at 2,994 metres (9,822 feet), is located in the municipality. However, the peak is in a straight line from the urban seat of the municipality, inaccessible except through the Amazon rainforest, and in both a national park and a Yanomami reservation under federal control and with restricted access.
The municipality also contains part of the Amazonas National Forest.
The city is served by Tapuruquara Airport.