| Santa Isabel District | |
| Mapsize: | 300px |
| Pushpin Map: | Panama |
| Pushpin Label Position: | right |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location of the district capital in Panama |
| Subdivision Type: | Country |
| Subdivision Name: |  Panama |
| Subdivision Type1: | Province |
| Subdivision Name1: | Colón Province |
| Subdivision Type2: | Capital |
| Subdivision Name2: | Palenque |
| Unit Pref: | Imperial |
| Area Total Km2: | 727 |
| Population As Of: | 2019 |
| Population Note: | official estimate[1] |
| Population Total: | 3973 |
| Population Density Km2: | auto |
| Population Blank1 Title: | Ethnicities |
| Timezone: | ETZ |
| Utc Offset: | -5 |
| Coordinates: | 9.5167°N -89°W |
Santa Isabel District (pronounced as /es/) is a district (distrito) of Colón Province in Panama. The population according to the 2000 census was 3,323;[2] the latest official estimate (for 2019) is 3,973.[3] The district, which lies in the east of the province along the Caribbean coast, covers a total area of 727 km². The capital lies at the town of Palenque.[2]
The district is divided administratively into the following corregimientos: