| Santa Isabel | |
| Native Name Lang: | es |
| Settlement Type: | Town |
| Pushpin Map: | Argentina |
| Pushpin Map Caption: | Location of Santa Isabel in Argentina |
| Coordinates: | -36.25°N -122°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Argentina |
| Subdivision Type1: | Province |
| Subdivision Type2: | Department |
| Subdivision Name2: | Chalileo |
| Unit Pref: | Metric |
| Population Total: | 2493 |
| Population Density Km2: | auto |
| Timezone1: | ART |
| Utc Offset1: | -3 |
| Postal Code Type: | CPA base |
| Postal Code: | L6321 |
| Area Code Type: | Dialing code |
| Area Code: | +54 2338 |
Santa Isabel is a town in the province of La Pampa, Argentina. It had 2,493 inhabitants at the, and is the head town of the Chalileo Department. It lies on the west of the province, 240 km from the provincial capital Santa Rosa, by National Route 143, near the junction of the borders of the provinces of La Pampa, San Luis and Mendoza, in the area of the Atuel River marshlands.