| Santa Isabel, Baja California | |
| Settlement Type: | City |
| Pushpin Label: | Santa Isabel |
| Pushpin Map: | Mexico |
| Pushpin Label Position: | above |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Baja California |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Mexicali |
| Population Blank1 Title: | Ethnicities |
| Population Blank2 Title: | Religions |
| Coordinates: | 32.6314°N -115.5756°W |
Santa Isabel (Spanish for "St. Elizabeth of Portugal") is a city in Mexicali Municipality, Baja California. The city had a population of 33,604 as of 2018.[1] Located just south of the US-Mexico border, Santa Isabel is a part of the Calexico–Mexicali metropolitan area.
The city is the location of Silicon Border.