| Official Name: | Santa Fe |
| Settlement Type: | Unincorporated community |
| Pushpin Map: | Indiana#USA |
| Subdivision Type: | Country |
| Subdivision Name: | United States |
| Subdivision Type1: | State |
| Subdivision Name1: | Indiana |
| Subdivision Type2: | County |
| Subdivision Name2: | Spencer |
| Subdivision Type3: | Township |
| Subdivision Name3: | Clay |
| Timezone: | Central (CST) |
| Utc Offset: | -6 |
| Timezone Dst: | CDT |
| Utc Offset Dst: | -5 |
| Elevation Footnotes: | [1] |
| Elevation Ft: | 469 |
| Coordinates: | 38.1114°N -86.9078°W |
| Postal Code Type: | ZIP code |
| Postal Code: | 47579 |
| Area Code: | 812 |
| Blank Name: | GNIS feature ID |
| Blank Info: | 443022 |
Santa Fe is an unincorporated community in Clay Township, Spencer County, in the U.S. state of Indiana.
Santa Fe was laid out in 1846.[2]
Santa Fe is located at 38.1114°N -86.9078°W.