| Official Name: | Santa Fe |
| Other Name: | La Fe |
| Settlement Type: | Town |
| Pushpin Map: | Cuba |
| Pushpin Relief: | 1 |
| Pushpin Label Position: | none |
| Pushpin Map Caption: | Location of Santa Fe in Cuba |
| Pushpin Mapsize: | 280 |
| Subdivision Type: | Country |
| Subdivision Name: |  Cuba |
| Subdivision Type1: | Province |
| Subdivision Name1: | Isla de la Juventud |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Isla de la Juventud (seat: Nueva Gerona) |
| Established Title: | Founded |
| Established Date: | ? |
| Population As Of: | 2012 |
| Population Density Km2: | auto |
| Timezone: | EST |
| Utc Offset: | -5 |
| Coordinates: | 21.7447°N -82.7573°W |
| Elevation M: | 20 |
Santa Fe, also named La Fe,[1] is the second largest town on Isla de la Juventud of Cuba.
The town is located 20 km south of Nueva Gerona, the island's seat and main town. It was the first settlement on the island, built around mineral springs. Santa fe is linked with Nueva Gerona with a 15 km-long expressway.