| Official Name: | Santa Fé |
| Other Name: | Guadalupe Colon |
| Nickname: | Giriga |
| Pushpin Map: | Honduras |
| Pushpin Label Position: | left |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Honduras |
| Subdivision Type: | Country |
| Subdivision Name: | Honduras |
| Subdivision Type1: | Department |
| Subdivision Name1: | Colón |
| Area Total Km2: | 196 |
| Population As Of: | 2016 |
| Settlement Type: | Municipality |
| Population Total: | 5390[1] |
| Population Density Km2: | auto |
| Coordinates: | 15.9167°N -88°W |
Santa Fe is a municipality in the Honduran department of Colón.
Notable people from Santa Fe include Miriam Miranda, a Honduran human rights activist who advocates for the land rights of the Garífuna people.[2]
