| Official Name: | Santa Fé de Goiás |
| Settlement Type: | Municipality |
| Pushpin Map: | Brazil |
| Pushpin Map Caption: | Location in Brazil |
| Coordinates: | -15.77°N -51.0958°W |
| Subdivision Type: | Country |
| Subdivision Name: | Brazil |
| Subdivision Type1: | Region |
| Subdivision Name1: | Central-West |
| Subdivision Type2: | State |
| Subdivision Name2: | Goiás |
| Subdivision Type3: | Mesoregion |
| Subdivision Type4: | Microregion |
| Subdivision Name4: | Rio Vermelho Microregion |
| Subdivision Type5: | Metrop. region |
| Leader Title: | Mayor |
| Elevation M: | 362 |
| Area Total Km2: | 1160.8 |
| Population Total: | 4,762 |
| Population As Of: | 2010 [1] |
| Population Density Km2: | auto |
| Timezone1: | BRT |
| Utc Offset1: | -3 |
| Postal Code Type: | Postal code |
| Postal Code: | 76265-000 |
| Area Code Type: | Area code |
Santa Fé de Goiás is a municipality in the west-central Brazilian state of Goiás.
Santa Fé is located almost directly west of Brasília and northwest of Goiânia. The nearest town of any size is Jussara, which lies 34 km. to the southeast.
Neighboring municipalities: Jussara, Britânia, Itapirapuã
In 1957, Santa Fé de Goiás became a district belonging to Goiás. In 1958, it was dismembered to become a district in the municipality of Jussara. In 1988, it got its municipal autonomy.
The economy is based on subsistence agriculture, cattle raising, services, public administration, and small transformation industries.