| Settlement Type: | city |
| Official Name: | Santa Cruz del Comercio |
| Subdivision Name2: | Santa Cruz del Comercio |
| Area Total Km2: | 17 |
| Elevation M: | 739 |
| Population Density Km2: | auto |
| Utc Offset: | +1 |
| Utc Offset Dst: | +2 |
Santa Cruz del Comercio is a municipality located in the province of Granada, Spain. According to the 2005 census (INE), the city has a population of 544 inhabitants.
During the Granadin earthquake of 25 December 1884, more than 70% of the houses collapsed and 20% were severely damaged. There were 13 dead and 19 injured.