| Official Name: | Santa Cruz de la Sierra |
| Pushpin Map: | Spain |
| Pushpin Map Caption: | Location in Spain |
| Subdivision Name3: | La Carballeda |
| Elevation M: | 716 |
| Population As Of: | 2012 |
| Population Total: | 35[1] |
| Coordinates: | 39.3361°N -5.8464°W |
| Area Code: | (+34) 980 |
Santa Cruz de la Sierra is a municipality located in the province of Cáceres and autonomous community of Extremadura, Spain. The municipality covers an area of and had a population of 278 people.[2]