| Santa Cruz River | |
| Pushpin Map: | New Mexico |
| Subdivision Type1: | Country |
| Subdivision Name1: | United States |
| Subdivision Type2: | State |
| Subdivision Name2: | New Mexico |
| Subdivision Type3: | Counties |
| Subdivision Name3: | Rio Arriba, Santa Fe |
| Source1 Location: | Cundiyo, New Mexico |
| Mouth Location: | Espanola, New Mexico |
| River System: | Rio Grande |
The Santa Cruz River of New Mexico is a tributary of the Rio Grande at Española, New Mexico. The Santa Cruz River valley is the site of El Santuario de Chimayo, a mission chapel built by early Spanish colonists of the Santa Fe area.[1]