| Santa Cruz Mixtepec | |
| Settlement Type: | Municipality and town |
| Pushpin Map: | Mexico |
| Pushpin Label Position: | above |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Oaxaca |
| Population As Of: | 2005 |
| Timezone: | Central Standard Time |
| Utc Offset: | -6 |
| Timezone Dst: | Central Daylight Time |
| Utc Offset Dst: | -5 |
| Coordinates: | 16.8°N -148°W |
Santa Cruz Mixtepec is a town and municipality in Oaxaca in south-western Mexico. The town covers an area of 66.34 km². It is part of the Zimatlán District in the west of the Valles Centrales Region
In 2005, the municipality had a population of 2,984.[1]
The church is notable for a number of colonial-era santos or statues of the saints, many of them executed in fine polychrome that has been well preserved.[2]