| Santa Cruz District | |
| Native Name Lang: | es |
| Settlement Type: | District |
| Mapsize: | frameless |
| Subdivision Type: | Country |
| Subdivision Name: |  Peru |
| Subdivision Type1: | Region |
| Subdivision Name1: | Loreto |
| Subdivision Type2: | Province |
| Subdivision Name2: | Alto Amazonas |
| Parts Type: | Subdivisions |
| Parts Style: | para |
| Established Title: | Founded |
| Established Date: | February 7, 1866 |
| Seat Type: | Capital |
| Seat: | Santa Cruz |
| Leader Title: | Mayor |
| Leader Name: | Persi Ruiz Cainamari |
| Unit Pref: | Metric |
| Area Total Km2: | 1093.61 |
| Elevation M: | 149 |
| Population Total: | 4447 |
| Population As Of: | 2005 census |
| Population Density Km2: | auto |
| Timezone1: | PET |
| Utc Offset1: | -5 |
| Blank Name Sec1: | UBIGEO |
| Blank Info Sec1: | 160210 |
Santa Cruz District is one of six districts of the province Alto Amazonas in Peru.[1]