Santa Cruz Biotechnology Explained

Santa Cruz Biotechnology, Inc. (SCBT) is a developer of biological products for medical research,[1] [2] and is one of the world's largest suppliers of antibodies.[3] Santa Cruz Biotechnology headquarters are located in Dallas, Texas, with additional US facilities in Paso Robles, California,[4] and Sun Valley, Idaho. The company also has international locations in Germany, Shanghai, and Canada.[5] It is focused on the production of research tools and reagents, which also include biochemicals, labware, and CRISPR products.[6]

History

SCBT was founded in 1991 by Dr. John Stephenson and his wife Brenda Stephenson in Santa Cruz, California.[7] The company was originally headquartered in Santa Cruz, California, where the Stephensons acquireed vast tracks of land,[8] and began offering antibodies to the research community.[9] Other products lines were added over the years – siRNAs in 2007,[10] shRNAs in 2009,[11] and laboratory supplies in 2010.

In 2010, the offering of biochemical was expanded from just a few hundred to over 100,000 different products.[12] Products related to CRISPR were introduced in 2015[13] for over 37,000 mouse and human genes.

Santa Cruz Biotechnology has had issues with the USDA for a number of years due to allegations of Animal Welfare Act violations. Three animal-welfare complaints were lodged after inspectors found evidences of animal mistreatment at the company's facility in California. In May 2016, the company settled with the USDA, paying a $3.5 million fine for its alleged violations and agreed to the revocation of its polyclonal antibody dealer license effective from December 31, 2016.[14] [15] The fine is considered the largest in the USDA's history.

Santa Cruz Biotechnology is currently the second largest vendor in the antibody market.

Notes and References

  1. Web site: Santa Cruz Biotechnology opens office in Idaho.
  2. Web site: Santa Cruz Biotechnology, Inc.: Private Company Information - Bloomberg. .
  3. Web site: Economic growth pushes SLO County higher in national ranking.
  4. Web site: Paso Robles Press Santa Cruz Biotech breaks ground on new building.
  5. Web site: Santa Cruz Biotechnology Opens New Office in Canada.
  6. Web site: Sterling . John . 2023-08-14 . ERS Genomics Inks CRISPR Deal with Santa Cruz Biotechnology . 2024-05-08 . GEN - Genetic Engineering and Biotechnology News . en-US.
  7. Web site: Idaho Mountain Express: Biotechnology firm sets up shop in Ketchum - December 3, 2008 .
  8. News: Ferguson . Cat . 2014-02-12 . Valuable Antibodies at a High Cost . 2024-05-08 . The New Yorker . en-US . 0028-792X.
  9. 238044. 1993. Jeang. K. T.. In vitro and in vivo binding of human immunodeficiency virus type 1 Tat protein and Sp1 transcription factor. Journal of Virology. 67. 10. 6224–6233. Chun. R. Lin. N. H.. Gatignol. A. Glabe. C. G.. Fan. H. 10.1128/JVI.67.10.6224-6233.1993. 7690421.
  10. Adiponectin modulates inflammatory reactions via calreticulin receptor–dependent clearance of early apoptotic bodies. Yukihiro. Takemura. Noriyuki. Ouchi. Rei. Shibata. Tamar. Aprahamian. Michael T.. Kirber. Ross S.. Summer. Shinji. Kihara. Kenneth. Walsh. 1 February 2007. J Clin Invest. 117. 2. 375–386. 10.1172/JCI29709. 17256056. 1770947.
  11. Embryonic stem cell differentiation into smooth muscle cells is mediated by Nox4-produced H2O2. American Journal of Physiology. Cell Physiology. Qingzhong. Xiao. Zhenling. Luo. Anna Elena. Pepe. Andriani. Margariti. Lingfang. Zeng. Qingbo. Xu. 1 April 2009. 296. 4. C711–C723. ajpcell.physiology.org. 10.1152/ajpcell.00442.2008. 19036941. 22623586 .
  12. EIF2A-dependent translational arrest protects leukemia cells from the energetic stress induced by NAMPT inhibition. Chiara. Zucal. Vito G.. D’Agostino. Antonio. Casini. Barbara. Mantelli. Natthakan. Thongon. Debora. Soncini. Irene. Caffa. Michele. Cea. Alberto. Ballestrero. Alessandro. Quattrone. Stefano. Indraccolo. Alessio. Nencioni. Alessandro. Provenzani. 5 November 2015. BMC Cancer. 15. 855. 10.1186/s12885-015-1845-1. 26542945. 4636066 . free .
  13. The mannose receptor LY75 (DEC205/CD205) modulates cellular phenotype and metastatic potential of ovarian cancer cells. Adnen. Faddaoui. Magdalena. Bachvarova. Marie. Plante. Jean. Gregoire. Marie-Claude. Renaud. Alexandra. Sebastianelli. Stephane. Gobeil. Chantale. Morin. Elizabeth. Macdonald. Barbara. Vanderhyden. Dimcho. Bachvarov. 9 February 2016. Oncotarget. 7. 12. 14125–14142. 10.18632/oncotarget.7288. 26871602. 4924702.
  14. Web site: 2023-06-13 . Santa Cruz Biotechnology and the USDA – Speaking of Research . 2024-01-14 . https://web.archive.org/web/20230613023206/https://speakingofresearch.com/2016/06/16/santa-cruz-biotechnology-and-the-usda/ . 2023-06-13 .
  15. US government issues historic $3.5-million fine over animal welfare. Nature. Sara. Reardon. 10.1038/nature.2016.19958. 2016. 168547955 .

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