| Santa Cruz | |
| Coordinates: | 15.134°N -23.56°W |
| Key: | 73120 |
Santa Cruz is a settlement in the eastern part of the island of Santiago, Cape Verde. It is part of the municipality of Santa Cruz. It is located 2 km south of Cancelo and 3 km west of Pedra Badejo, on the national road to Tarrafal (EN1-ST02). In 2010 its population was 2,019.