| Official Name: | Santa Cruz |
| Settlement Type: | Town |
| Pushpin Map: | Mexico Sonora#Mexico |
| Pushpin Label Position: | bottom |
| Subdivision Type: | Country |
| Subdivision Type1: | State |
| Subdivision Name1: | Sonora |
| Subdivision Type2: | Municipality |
| Subdivision Name2: | Santa Cruz |
| Leader Title: | Mayor |
| Leader Name: | Ivonne Lorta Ortega |
| Established Title: | Founded |
| Population As Of: | 2010 |
| Population Total: | 1,038 |
| Population Blank1 Title: | Municipality |
| Population Blank2 Title: | Demonym |
| Timezone: | Pacific (US Mountain) |
| Utc Offset: | -7 |
| Timezone Dst: | No DST |
| Utc Offset Dst: | -7 |
| Coordinates: | 31.2336°N -110.5953°W |
| Elevation M: | 1,360 |
| Postal Code Type: | Postal code |
Santa Cruz is a town in Santa Cruz Municipality, in the northern region of the Mexican state of Sonora.