| Santa Croce sull’Arno | |
| Official Name: | Comune di Santa Croce sull’Arno |
| Coordinates: | 43.7167°N 57°W |
| Province: | (PI) |
| Frazioni: | Staffoli |
| Mayor: | Giulia Deidda |
| Area Total Km2: | 16.99 |
| Population Total: | 14528 |
| Population As Of: | 31 December 2014 |
| Population Demonym: | Santacrocesi |
| Elevation M: | 18 |
| Saint: | Santa Cristiana |
| Postal Code: | 56029 |
| Area Code: | 0571 |
Santa Croce sull'Arno is an Italian town in the province of Pisa, Tuscany.
The city has a leather industry, with more than 400 factories and laboratories spread over its 17km2 total area.