| Religious Affiliation: | Catholicism |
| Locale: | Naples |
| Rite: | Roman |
| Region: | Campania |
| Country: |  Italy |
| Consecration Year: | 1791 |
| Architect: | Francesco Sicuro |
| Groundbreaking: | 1786 |
40.8477°N 14.2657°WSanta Croce e Purgatorio al Mercato is a church in the center of the Piazza Mercato, in Naples, Italy.
A religious building has stood at this site since the 13th century when Conradin of Swabia was decapitated by orders of Charles I d'Anjou, on October 29, 1268. A porphyry column at the site read: Asturis ungue, leo pullum rapiens aquilinum; hic deplumavit acephalumque dedit which loosely translates: At the point of Astura, the lion seized the eagle, here without feathers, gave his head. This references the capture of Conradin (eagle) by the Angevin (Lion) at the Torre Astura, and subsequent beheading here without honor.
In 1786 it was reconstructed by Francesco Sicuro, and again in 1781, after a fire destroyed the piazza and church. The church was damaged by the earthquake in 1980, and has been closed since then. Originally the church held paintings by Luca Giordano, but these have been transferred to the Museo Civico di Castel Nuovo.