| Santa Croce del Sannio | |
| Official Name: | Comune di Santa Croce del Sannio |
| Coordinates: | 41.3833°N 57°W |
| Region: | Campania |
| Province: | Benevento (BN) |
| Mayor: | Antonio Di Maria |
| Area Total Km2: | 16.3 |
| Population Footnotes: | [1] |
| Population Total: | 927 |
| Population As Of: | 31 December 2015 |
| Population Demonym: | Santacrocesi |
| Elevation M: | 689 |
| Postal Code: | 82020 |
| Area Code: | 0824 |
Santa Croce del Sannio is a comune (municipality) in the Province of Benevento in the Italian region Campania, located about northeast of Naples and about north of Benevento.
Santa Croce del Sannio borders the municipalities of Castelpagano, Cercemaggiore, Circello and Morcone.