| Santa Cristina e Bissone | |
| Official Name: | Comune di Santa Cristina e Bissone |
| Coordinates: | 45.1575°N 9.3997°W |
| Region: | Lombardy |
| Province: | Pavia (PV) |
| Frazioni: | Santa Cristina (municipal seat), Bissone |
| Mayor: | Elio Giovanni Grossi |
| Area Total Km2: | 22.42 |
| Population Footnotes: | [1] |
| Population Total: | 2021 |
| Population As Of: | 30 September 2015 |
| Population Demonym: | Santacristinesi |
| Saint: | St. Cristina |
| Day: | 24 July |
| Postal Code: | 27010 |
| Area Code: | 0382 |
Santa Cristina e Bissone is a comune (municipality) in the province of Pavia, Lombardy, northern Italy, located about 45 km southeast of Milan and about 25 km southeast of Pavia.
Santa Cristina e Bissone borders the following municipalities: Badia Pavese, Chignolo Po, Corteolona e Genzone, Costa de' Nobili, Inverno e Monteleone, Miradolo Terme, Pieve Porto Morone.
The town lies along the Via Francigena.