| Santa Cesarea Terme | |
| Official Name: | Comune di Santa Cesarea Terme |
| Shield Alt: | coat of arms of the commune |
| Pushpin Label Position: | left |
| Coordinates: | 40.0333°N 46°W |
| Region: | Apulia |
| Province: | (LE) |
| Frazioni: | Cerfignano, Porto Miggiano, Vitigliano |
| Mayor: | Pasquale Bleve |
| Area Total Km2: | 26 |
| Population Footnotes: | [1] |
| Population Total: | 3017 |
| Population As Of: | 31 December 2017 |
| Population Demonym: | Cesarini |
| Elevation M: | 56 |
| Saint: | Santa Cesarea |
| Day: | 12 September |
| Postal Code: | 73020 |
| Area Code: | 0836 |
Santa Cesarea Terme (Salentino: Sicilian: Santa Cisaria) is a town and comune in the province of Lecce, Apulia, southern Italy.
Situated on the coast at the entrance of the Strait of Otranto, on a part of the coast which comes down to the sea, the town of Santa Cesarea is one of the largest centers for thermal baths in the Salento. The use of the waters, coming from four caves, dates back to the 16th century. The economy of the whole town is based on the baths, which offer various facilities.