| Santa Casa de Misericórdia of Santo Amaro | |
| Native Name: | Santa Casa de Misericórdia de Santo Amaro |
| Map Type: | Brazil |
| Building Type: | philanthropic organization and hospital |
| Location City: | Santo Amaro, Bahia |
| Location Country: | Brazil |
| Coordinates: | -12.5472°N -38.711°W |
| Completion Date: | 1778 |
| Destruction Date: | --> |
| Floor Count: | 2 |
| Floor Area: | 1347m2 |
| Unit Count: | --> |
The Santa Casa de Misericórdia of Santo Amaro (Portuguese: Santa Casa de Misericórdia de Santo Amaro) is an 18th-century philanthropic and medical building in Santo Amaro, Bahia, Brazil. The building was completed in 1778, following the construction of the Parish Church of Our Lady of Purification (completed ca. 1727) and the Town Hall of Santo Amaro (1769). The Santa Casa de Misericórdia of Santo Amaro faces the Parish Church of Our Lady of Purification in the Historic Center of Santo Amaro. The building contains the Hospital Nossa Senhora da Natividade and still functions as a hospital in Santo Amaro.
It has two stories, and covers 1347m2. The structure was developed around a courtyard to facilitate illumination and air circulation. This feature was common to large public buildings of the period, notably the Asilo Santa Isabela in Salvador and later in the Agricultural School of São Bento das Lages (Escola Agrícola de São Bentodas Lages) in São Francisco do Conde.
The Santa Casa de Misericórdia of Santo Amaro was listed as a historic structure by the National Institute of Historic and Artistic Heritage in 1941 under inscription number 287.