| Native Name: | Portuguese: Santa Casa da Misericórdia |
| Address: | Travessa da Misericórdia, n.o 7 |
| Grid Name: | SAR |
| Grid Position: | Macau |
The Holy House of Mercy of Macau (Portuguese: Santa Casa da Misericórdia;), is a historic building in Senado Square, Sé, Macau. Established as a branch of the Santa Casa da Misericórdia, it was first built in 1569 on the orders of the Bishop of Macau, Belchior Carneiro Leitão.
It was a medical clinic and several other social welfare structures in early Macau. It later served as an orphanage and refuge for widows of sailors lost at sea.
It is part of the Historic Centre of Macau, a UNESCO World Heritage Site.