| Santa Bárbara Department | |
| Native Name: | Departamento de Santa Bárbara |
| Native Name Lang: | es |
| Settlement Type: | department |
| Pushpin Label Position: | bottom |
| Pushpin Map Caption: | Location in Honduras |
| Coordinates: | 14.9167°N -102°W |
| Subdivision Type: | Country |
| Subdivision Name: |  Honduras |
| Subdivision Type1: | Municipalities |
| Subdivision Name1: | 28 |
| Subdivision Type2: | Villages |
| Subdivision Name2: | 370 |
| Established Title: | Founded |
| Established Date: | 28 June 1825 |
| Seat Type: | Capital city |
| Seat: | Santa Bárbara |
| Government Type: | Departmental |
| Leader Party: | PNH |
| Leader Title: | Gobernador |
| Leader Name: | Wilman Ottoniel Pineda (2018–2022) |
| Unit Pref: | Metric |
| Area Total Km2: | 5013 |
| Population As Of: | 2015 |
| Population Total: | 434896 |
| Population Density Km2: | auto |
| Demographics Type1: | GDP (Nominal, 2015 US dollar) |
| Demographics1 Title1: | Total |
| Demographics1 Info1: | $1.3 billion (2023)[1] |
| Demographics1 Title2: | Per capita |
| Demographics1 Info2: | $2,300 (2023) |
| Demographics2 Title2: | Total |
| Demographics2 Info2: | $2.6 billion (2023) |
| Demographics2 Title3: | Per capita |
| Demographics2 Info3: | $4,900 (2023) |
| Timezone1: | CDT |
| Utc Offset1: | -6 |
| Postal Code Type: | Postal code |
| Postal Code: | 22101 |
| Iso Code: | HN-SB |
| Blank Name Sec1: | HDI (2021) |
| Blank Info Sec1: | 0.593[2] · 9th of 18 |
| Footnotes: | Statistics derived from Consult INE online database: Population and Housing Census 2013[3] |
Santa Bárbara is one of the 18 departments (departamentos) into which Honduras is divided. The departmental capital is Santa Bárbara.
The department covers a total surface area of 5,115 km² and, in 2005, had an estimated population of 368,298 people.
The department, historically, is known for harvesting mahogany and cedar trees for exportation.[4]