| Santa Barbara, Nariño | |
| Settlement Type: | Municipality and town |
| Mapsize: | 250px |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Name: |  Colombia |
| Subdivision Type1: | Department |
| Subdivision Name1: | Nariño Department |
| Area Footnotes: | [1] |
| Area Total Km2: | 1300 |
| Population As Of: | Census 2018[2] |
| Population Total: | 8989 |
| Population Density Km2: | auto |
| Timezone: | Colombia Standard Time |
| Utc Offset: | -5 |
Santa Bárbara is a town and municipality in the Nariño Department, Colombia. Its municipal seat is known as Iscuandé.
Santa Bárbara has a tropical rainforest climate (Köppen Af) with very heavy rainfall year-round.