| Santa Ana Zegache | |
| Settlement Type: | Municipality and town |
| Pushpin Map: | Mexico |
| Pushpin Label Position: | above |
| Pushpin Mapsize: | 300 |
| Pushpin Map Caption: | Location in Mexico |
| Subdivision Type: | Country |
| Subdivision Name: |  Mexico |
| Subdivision Type1: | State |
| Subdivision Name1: | Oaxaca |
| Population As Of: | 2005 |
| Timezone: | Central Standard Time |
| Utc Offset: | -6 |
| Timezone Dst: | Central Daylight Time |
| Utc Offset Dst: | -5 |
| Coordinates: | 16.8359°N -96.7295°W |
Santa Ana Zegache is a town and municipality in Oaxaca in south-western Mexico. The municipality covers an area of 26.79 km². It is part of the Ocotlán District in the south of the Valles Centrales Region
As of 2005, the municipality had a total population of 3,196.[1]
A project dedicated to restoring artifacts from the church, Zegache Talleres Comunitarios, was founded by painter Rodolfo Morales, and continues to employ and train many local people.
Yatzeche Zapotec was formerly spoken in the town.[2]