| Settlement Type: | town |
| Official Name: | Santa Ana |
| Pushpin Map: | Colombia |
| Pushpin Map Caption: | Location in Colombia |
| Subdivision Type: | Country |
| Subdivision Type1: | Region |
| Subdivision Type2: | Department |
| Subdivision Name: | Colombia |
| Subdivision Name1: | Caribbean |
| Leader Title: | Mayor |
| Established Title: | Foundation |
| Established Date: | 1751 |
| Population As Of: | Census 2018[1] |
| Population Total: | 22723 |
| Utc Offset: | -5 |
| Coordinates: | 9.319°N -74.57°W |
| Website: | www.santaana-magdalena.gov.co |
Santa Ana is a town and municipality of the Magdalena Department in northern Colombia. Founded in 1751 by José Fernando de Mier y Guerra with the name of Santa Ana de Buena Vista. In 1918 was established as a municipality.