| Saint Alphys | |
| Official Name: | Comune di Sant'Alfio |
| Coordinates: | 37.75°N 23°W |
| Region: | Sicily |
| Metropolitan City: | Catania (CT) |
| Mayor: | Giuseppe Maria Nicotra |
| Area Total Km2: | 23.6 |
| Population Footnotes: | [1] |
| Population Total: | 1582 |
| Population As Of: | 31 December 2015 |
| Population Demonym: | Santalfiesi |
| Elevation M: | 531 |
| Saint: | Sts. Alphys, Philadelphus and Cyrinus |
| Postal Code: | 95010 |
| Area Code: | 095 |
Saint Alphys (in Italian: Sant'Alfio) or (scn|'''Sant'Arfiu''') is a comune (municipality) in the Metropolitan City of Catania in the Italian region Sicily, about 160km (100miles) east of Palermo and about 25km (16miles) north of Catania.
Saint Alphys borders the following municipalities: Adrano, Belpasso, Biancavilla, Bronte, Castiglione di Sicilia, Giarre, Linguaglossa, Maletto, Mascali, Milo, Nicolosi, Piedimonte Etneo, Randazzo, Zafferana Etnea.