| San Leone | |
| Mouth: | Mediterranean Sea |
| Mouth Location: | San Leone |
| Pushpin Map: | Italy Sicily |
| Pushpin Map Caption: | Location in Sicily |
| Subdivision Type1: | Country |
| Subdivision Name1: | Italy |
| Subdivision Type2: | Region |
| Subdivision Name2: | Sicily |
| Length: | 26km2 |
| Basin Size: | 206km2 |
The San Leone is a river in the Province of Agrigento, Sicily, Italy. Its main stream is long, and it has a drainage basin of .[1] Its source is in the commune of Santa Elisabetta and it discharges into the Mediterranean Sea in San Leone, a frazione of the city of Agrigento. It has various names along its course: at its source it is called Akragas, further downstream Drago, then Sant'Anna (the ancient Hypsas)[2] and the final 3 km until its mouth San Leone. Its largest tributary is the San Biagio (also: San Benedetto).[1] In the 19th century it was known as Fiume di Girgenti.[3]