Sanofi Explained

Sanofi S.A.
Type:Société Anonyme
Products:Medications, generic drugs, over-the-counter drugs, vaccines, diagnostics, contact lenses, animal health (list...)
Revenue Year:2023
Operating Income: €7.875 billion
Income Year:2023
Net Income: €5.436 billion
Net Income Year:2023
Assets: €126.4 billion
Assets Year:2023
Equity: €74.35 billion
Equity Year:2023
Num Employees:86,088
Num Employees Year:2023
Hq Location:Paris, France
Area Served:Worldwide
Footnotes:[1]

Sanofi S.A. is a French multinational pharmaceutical and healthcare company headquartered in Paris, France. The corporation was established in 1973 and merged with Synthélabo in 1999 to form Sanofi-Synthélabo. In 2004, Sanofi-Synthélabo merged with Aventis and renamed to Sanofi-Aventis, which were each the product of several previous mergers. It changed its name back to Sanofi in May 2011. The company is a component of the Euro Stoxx 50 stock market index.[2] In 2023, the company’s seat in Forbes Global 2000 was 89.[3]

Sanofi engages in the research and development, manufacturing, and marketing of pharmacological products, principally in the prescription market, but the firm also develops over-the-counter medications. The corporation covers seven major therapeutic areas: cardiovascular, central nervous system, diabetes, internal medicine, oncology, thrombosis, and vaccines (it is the world's largest producer of the last through its subsidiary Sanofi Pasteur).[4]

History

Sanofi-Synthélabo

Sanofi was founded in 1973[5] as a subsidiary of Elf Aquitaine (a French oil company subsequently acquired by Total), when Elf Aquitaine took control of the Labaz group, a pharmaceutical company formed in 1947 by Sociéte Belge de l'Azote et des Produits Chimiques du Marly;[6] Labaz developed benziodarone in 1957.[7] In 1993, Sanofi made a move into the Eastern Europe market by acquiring a controlling interest in Chinoin, a Hungarian drug company whose 1992, sales totaled about US$104 million.[8] [9] In the same year, Sanofi made its first significant venture into the US, and strengthened its presence in Eastern Europe, by first partnering with Sterling Winthrop and then acquiring the prescription pharmaceuticals business in 1994.[8] [10] Sanofi was incorporated under the laws of France in 1994, as a société anonyme, a form of limited liability company.[11]

Synthélabo was founded in 1970, through the merger of two French pharmaceutical laboratories, Laboratoires Dausse (founded in 1834)б and Laboratoires Robert & Carrière (founded in 1899). In 1973, the French cosmetics group L'Oréal acquired the majority of its share capital.[11] In 1991, Synthelabo acquired Laboratories Delalande[12] and Laboratoires Delagrange, and through this deal picked up the product metoclopramide.[13] [14]

Sanofi-Synthélabo was formed in 1999 when Sanofi merged with Synthélabo; at the time of the merger, Sanofi was the second largest pharmaceutical group in France in terms of sales and Synthélabo was the third largest. The merged company was based in Paris, France.[11] [15]

The merged companies focused on pharmaceuticals, divesting several businesses soon after the merger, including beauty, diagnostics, animal health and nutrition, custom chemicals, and two medical equipment businesses.[11]

Aventis

Aventis was formed in 1999, when the French company Rhône-Poulenc S.A. merged with the German corporation Hoechst Marion Roussel, which itself was formed from the 1995 merger of Hoechst AG with Cassella, Roussel Uclaf, and Marion Merrell Dow. Hoechst AG, the majority partner at the time in Hoechst Marion Roussel, was itself a merger of two of the three forcibly separated subsidiaries of IG Farben, exploiter of Auschwitz slave labor and supplier of Zyklon B during The Holocaust.[16] The merged company was based in Schiltigheim, near Strasbourg, France.[17] [18] [19]

At the time of the merger, Rhône-Poulenc's business included the pharmaceutical businesses Rorer, Centeon (blood products), and Pasteur Merieux (vaccines), the plant and animal health businesses Rhône-Poulenc Agro, Rhône-Poulenc Animal Nutrition, and Merial, and a 67 percent share in Rhodia, a speciality chemicals company.[18] Hoechst, one of the companies that resulted from the post-WWII split of IG Farben, had seven primary businesses: Hoechst Marion Roussel (pharmaceuticals), AgrEvo (a joint venture with Schering in crop protection agents and pest control products), HR Vet (veterinary products), Dade Behring (diagnostics), Centeon, Celanese (chemicals), and Messer (chemicals).[18] Merieux has been in the business of selling blood products, and in the 1980s, during the AIDS epidemic, Merieux and other companies were involved in scandals related to HIV-contaminated haemophilia blood products that were sold to developing nations.[20]

In 2000, Aventis and Millennium Pharmaceuticals, a US biotechnology company formed to discover new drugs based on the then-new science of genomics, announced that Aventis would make a $250M investment in Millennium and would pay $200M to Millennium in research fees over five years, one of the largest such deals between a big pharmaceutical company and a biotech company at the time.[21]

In late 2000, in the midst of the recall of Starlink, its genetically modified maize product, Aventis announced that it had determined to sell off Aventis Cropscience, the seed and pesticide business unit it had created from the agriculture businesses of its predecessors.[22] In October 2001, Bayer and Aventis announced that Bayer would acquire the unit for about $6.6 billion; the unit became Bayer CropScience, making Bayer the world's second-largest agrochemical company behind Syngenta.[23]

In 2003, Aventis entered into a collaboration with Regeneron Pharmaceuticals, a New York biotechnology company, to develop Regeneron's VEGF-inhibiting drug, aflibercept, which was then in Phase I clinical trials. Aventis invested $45 million in Regeneron and made an upfront payment of $80 million in cash.[24] Regeneron partnered the use of the drug with Bayer Healthcare in the field of proliferative eye diseases, and under the name Eylea it was approved by the US Food and Drug Administration (FDA) in 2011;[25] after several setbacks in clinical trials,[26] Regeneron and Sanofi got the drug approved for metastatic colorectal cancer in combination with other agents, under the brand name Zaltrap in 2012.[27]

Sanofi-Aventis merger

Sanofi-Aventis was formed in 2004, when Sanofi-Synthélabo acquired Aventis. In early 2004, Sanofi-Synthélabo made a hostile takeover bid for Aventis worth €47.8 billion. Initially, Aventis rejected the bid because it felt that the bid offered inferior value based on the company's share value, and the board of Aventis went so far as to enact poison pill provisions and to invite Novartis to enter merger negotiations.[28] The three-month takeover battle concluded when Sanofi-Synthélabo launched a friendly bid of €54.5 billion in place of the previously rejected hostile bid. The French government played a strong role, desiring what it called a "local solution", by putting heavy pressure on Sanofi-Synthélabo to raise its bid for Aventis and for Aventis to accept the offer[29] and by rejecting Aventis's poison pill proposal.[30] One of the largest risks in the deal for both sides was the fate of the patents protecting Clopidogrel (Plavix), which was one of the top-selling drugs in the world at the time and the major source of Sanofi's revenue.[31]

Post-merger activities

In 2006, Iraqis infected with HIV sued Sanofi and Baxter over HIV-contaminated haemophilia blood products sold by Merieux in the 1980s.[32] In 2006, the US patents on clopidogrel (Plavix) were challenged when a Canadian generics company, Apotex, filed an Abbreviated New Drug Application under the Hatch-Waxman Act, received FDA approval, and started marketing a generic formulation of clopidogrel. While Sanofi-Aventis and its partner in the drug, Bristol Myers Squibb (BMS), were able to get an injunction to stop Apotex from selling it,[33] the case became complicated when settlement negotiations fell apart twice – the second time because of an oral agreement made by BMS CEO Peter Dolan that BMS failed to disclose to the Federal Trade Commission during the review of the settlement agreement to ensure that it did not violate antitrust law. When Apotex disclosed the oral agreement to the FTC, the FTC launched an investigation that led to Dolan's dismissal by BMS.[34] Apotex finally lost on the patent litigation issues after its third appeal was decided in favor of BMS/Sanofi in November 2011; Apotex had to pay ~$442 million in damages and ~$108 million in interest for infringing the patent,[35] which it paid in full by February 2012.[36] Apotex also sued BMS and Sanofi for $3.4 billion for allegedly breaching the settlement agreement; Apotex lost a jury trial in March 2013.[37]

In 2007, Sanofi-Aventis expanded on Aventis's prior relationship with Regeneron Pharmaceuticals; in the new deal Sanofi-Aventis agreed to pay Regeneron $100 million per year for five years, under which Regeneron would use its monoclonal antibody discovery platform to create new biopharmaceuticals, to which Sanofi-Aventis gained the exclusive right to co-develop.[38] In 2009, the companies expanded the deal to $160 million per year and extended it to 2017.[38] [39], the collaboration had four antibodies in clinical development and had filed an IND for a fifth. Two were against undisclosed targets, one targeted the interleukin-6 receptor as a treatment for rheumatoid arthritis, another targeted nerve growth factor for the treatment of pain, and another targeted delta-like ligand 4 as a cancer treatment.[39]

Between 2008, when Chris Viehbacher was hired as CEO, and 2010, the company spent more than $17 billion in mergers and acquisitions to strengthen its consumer healthcare and generics platforms, especially in emerging markets, in the face of looming patent cliffs and the growth of the consumer healthcare segment.[40] [41] In September, Zentiva was acquired for €1.8 billion, expanding the group's presence in eastern European markets.[42]

In 2009, Medley Farma, the third largest pharmaceutical company in Brazil and a leading generics company there, was acquired for about $635 million.[43] Sanofi outbid Teva Pharmaceuticals.[44] The deal was approved by Brazil's antitrust authorities in May 2010.[43] Later that year, Indian vaccine manufacturer Shantha Biotechnics was acquired for $784 million.[45] In October Sanofi-Aventis announced that it would lay off about 1700 US employees (about 25% of its US workforce) because of restructuring triggered by growing generic competition and other factors, and that the company would focus its US operations on diabetes, atrial fibrillation, and oncology.[46]

In 2010, US consumer healthcare company Chattem, Inc. was acquired for around $1.9 billion.[47] In the same year, Nepentes Pharma was acquired for $130 million and BMP Sunstone Corporation for $520.6 million.[48]

Name change, acquisitions and investments

The company dropped the -Aventis suffix of its name on May 6, 2011, after receiving approval at its annual general meeting. The reason given by the company for the change was to make its name easier to pronounce in countries such as China.[49]

In 2011, Genzyme Corporation was acquired for around $20.1 billion. This biotechnology company, headquartered in Cambridge, Massachusetts, specializes in the treatment of orphan diseases, renal diseases, endocrinology, oncology, and biosurgery.[50]

In January 2012, Sanofi co-invested in the $125 million Series A financing of Warp Drive Bio. Sanofi sought support for its internal cancer research program and also took on an obligation to acquire Warp Drive if certain milestones were met.[51]

In January 2014, Genzyme and Alnylam Pharmaceuticals, a US biotechnology company developing RNAi therapeutics, announced that Genyzme would invest $700 million in Alnylam. Under the deal, Genzyme obtained further rights to patisiran, an RNAi treatment for transthyretin-mediated amyloidosis – a condition that can result in familial amyloidotic polyneuropathy and familial amyloidotic cardiomyopathy[52] and obtained rights to other compounds in Alnylam's pipeline.[53]

In March 2014, Sanofi joined the bidding for Merck & Co.'s over-the-counter health-products unit, the maker of Coppertone sunblock and the antihistamine Claritin; bids were expected to range between $10 billion and $12 billion.[54]

In October 2014, Sanofi's directors fired US-resident chief executive Chris Viehbacher, blaming his alleged lack of communication with the board and poor execution of his strategy.[55] Board chairperson Serge Weinberg took over as interim CEO until 2 April 2015 when Bayer Healthcare board chairman Olivier Brandicourt (appointed by Sanofi on 19 February 2015[56]) took over. Before Brandicourt even started his new job, French government ministers Stéphane Le Foll and Ségolène Royal attacked the $4.5 million golden handshake he was getting from Sanofi – and his pay of about $4.7 million a year.[57] Furthermore, in 2014, the business took a 66% stake in Globalpharma, a Dubai-based generics manufacturer.[58]

In July 2015, Genzyme announced that it would acquire the cancer drug Caprelsa (vandetanib) from AstraZeneca for up to $300 million.[59] In the same month, the company announced a new global collaboration with Regeneron Pharmaceuticals to discover, develop, and commercialize new immuno-oncology drugs, which could generate more than $2 billion for Regeneron,[60] with $640 million upfront, $750 million for proof of concept data, and $650 million from the development of REGN2810.[61]

In June 2016, the company announced that it had struck an asset-swap deal with Boehringer Ingelheim. Sanofi would sell its Merial animal health division (valuing it at €11.4 billion), while acquiring Boehringer's consumer health division (valuing it at €6.7 billion) and €4.7 billion in cash. The deal meant that Sanofi was now one of the global consumer healthcare leaders by market share.[62]

In July 2017, the company announced its intention to acquire Protein Sciences, a privately held Connecticut-based vaccines biotechnology company, for $650 million and with up to $100 million in milestone achievements.[63]

In January 2018, Sanofi announced that it would acquire Bioverativ for $11.6 billion[64] and days later announced that it would acquire Ablynx for €3.9 billion ($4.8 billion).[65]

In December 2019, the company announced that it would acquire Synthorx for $2.5 billion ($68 per share), adding the lead product candidate THOR-707 (SAR444245), a form of interleukin-2 (IL-2) being developed for use against multiple solid tumors.[66] [67] In October 2022, Sanofi announced that it had stopped Phase 2 studies of THOR-707 (SAR444245) because the drug's efficacy “was lower than projected”.[68] Sanofi would take a roughly $1.6 billion impairment charge because of delays to the program.[69] [70]

In May 2020, Regeneron announced that it would repurchase around $5 billion of its shares held directly by Sanofi. Before the transaction, Sanofi had held 23.2 million Regeneron shares.[71] In June, the company announced that it had agreed a potential $2 billion deal with Translate Bio, expanding an already existing collaboration for COVID-19 treatments.[72] The company agreed to produce 60 million doses of a coronavirus vaccine for the United Kingdom government in July 2020. It used recombinant protein-based technology for Sanofi's flu vaccine along with GSK's pandemic technology and was seeking regulatory approval by the first half of 2021.[73] Sanofi also agreed to a $2.1 billion deal with the United States for 100 million doses.[74] In August, Sanofi announced that it would acquire Principia Biopharma for $3.7 billion, acquiring its BTK inhibitor program.[75] [76] [77] The acquisition was completed in September 2020.[78] In November, Sanofi announced that it would acquire Kiadis Pharma for €308 million (around $359 million, or €5.45 per share), expanding its immuno-oncology pipeline with the acquisition of Kiadis's three clinical compounds: K-NK002 in Phase II trials for hematopoietic stem cell transplants in blood cancer, K-NK003 for relapsed or refractory acute myeloid leukemia, and K-NK-ID101 for COVID-19.[79]

In January 2021, Sanofi announced that it would buy the British biotech Kymab Ltd and its potential first-in-class drug candidate – KY1005 –- for $1.45 billion.[80] [81] [82] In April, the business announced that it would acquire Tidal Therapeutics for up to $470m.[83] in August the company announced that it would acquire Translate Bio and its mRNA vaccine technology for $3.2 billion.[84] On 8 September 2021, Sanofi announced that it would acquire US biotech company Kadmon Corporation for $1.9 billion[85] On 18 November 2021, it was reported that Sanofi would be investing $180 million in French startup Owkin, whose predictive algorithms aim to improve the research and development of new cures against cancer.[86] In December, the company announced that it would acquire Origimm Biotechnology GmbH and its acne vaccine candidate (ORI-001),[87] [88] as well as Amunix Pharmaceuticals, for an initial $1 billion plus potentially $200 million in additional milestones.[89]

In April 2022, Sanofi broke ground on its biggest industrial investment, a $638m vaccine and enzymes production facility in Tuas, Singapore, targeted for completion in 2025.[90]

In March 2023, the company announced it would acquire Provention Bio and its type 1 diabetes therapy pipeline.[91]

In the fall of 2023, Sanofi announced plans to separate the OTC and focus on its key prescription production, increasing investment and reducing costs. The most likely way to separate a non-prescription division (about 11,000 employees, 2023 revenue — over $4 billion) is to create a public company headquartered in France. The division is planned for the fourth quarter of 2024.[92]

In December 2023, the company has signed a 140 million dollars partnership with Aqemia, a company that solves a mathematical equation that eliminates the need for heavy computing facilities with large computing power.[93]

In January 2024, Sanofi announced that it had agreed to buy a U.S. biotech firm Inhibrx for up to $2.2 billion, with a focus on obtaining Inhibrx's INBRX-101, an experimental treatment for Alpha-1 Antitrypsin Deficiency (AATD), an inherited rare disease that causes progressive deterioration of the lung tissue.[94]

Company financials

Historical financial data (in billions of euro)[95] [96] [97] [98] [99] [100] [101] ! Year !! 2001 !! 2002 !! 2003 !! 2004 !! 2005 !! 2006 !! 2007 !! 2008 !! 2009 !! 2010 !! 2011 !! 2012 !! 2013 !! 2014 !! 2015 !! 2016!2017!2018!2019
Revenue 6.069 7.448 8.048 14.87 27.31 28.37 28.05 27.57 29.31 30.38 33.39 34.95 30.97 31.69 34.54 33.8235.0734.4636.13
Net Income 1.098 1.640 1.865 -3.665 2.202 4.006 5.263 3.851 5.265 5.467 5.646 4.888 3.716 4.390 4.287 4.8008.424.312.81
Assets 18.23 17.36 17.42 82.85 86.24 77.76 71.91 71.99 80.25 85.26 100.7 100.4 96.06 97.39 102.3 104.799.81111.41112.74
Equity 12.75 12.60 12.74 41.63 46.40 45.60 44.54 44.87 48.32 53.10 56.19 57.35 56.9 56.12 58.05 57.7258.0758.8858.93
Note. In 2001—2004 – Sanofi-Synthélabo, in 2004—2011 – Sanofi-Aventis.

Acquisition history

Products

The following products are listed on the Sanofi Genzyme website. Generic drug names are given in parentheses following the brand name.

– Autoimmune

Product recall and effects: The epinephrine (adrenaline) auto-injection devices made by Sanofi SA currently on the market in the US and Canada were voluntarily recalled on 28 October 2015.[106] [107] The reason given by Sanofi was that the products had been found to potentially have inaccurate dosage delivery systems, which might include failure to deliver the drugs.[108] [109]

Sanofi US also added the following warning: If a patient experiencing a serious allergic reaction (i.e., anaphylaxis) did not receive the intended dose, there could be significant health consequences, including death, because anaphylaxis is a potentially life‑threatening condition.

In its news release on 28 October 2015, Sanofi Canada stated that it was "actively working with suppliers of alternative epinephrine auto-injectors to have a full stock available in Canada as soon as possible. Canadian customers were asked to immediately return the Allerject product to their local pharmacy to obtain an alternate epinephrine auto-injector."[110]

The US Food and Drug Administration (FDA) also filed a news release, confirming that the recall involved all Auvi-Q currently on the market in the United States. The FDA release went on to provide information for consumers re: exchanging the device for another brand of product, also provided on the Auvi-Q web site. Sanofi US would provide reimbursement for out of pocket costs incurred for the purchase of new, alternate epinephrine auto-injectors with proof of purchase.[111]

The alternate products expected to most commonly replace the recalled Sanofi devices were the EpiPens made by Mylan in the US and by Pfizer—under license from Mylan—in Canada.[112] Mylan already had an 85% market share of the auto-injectors in the USA[113] in the first half of 2015. Maylan was expected to benefit from the recall by its competitor Sanofi, according to a report published in the Fierce Pharma newsletter of 2 November 2015. As Bernstein analyst Ronny Gal wrote in a note to clients,"....it is very hard to see Auvi-Q returning to the market, as it will need to be redesigned and face uphill battle to recapture patient trust after the recall."[114] Gal also believed that the company would eventually have 95% of the epinephrine auto-injector market, according to another Fierce Pharma report on 3 November 2015.[115]

– Cardiovascular

– Dermatology

– Diabetes

– Endocrinology

– Gastroenterology

– Hematology

– Infectious diseases

– Metabolic

– Neurology

– Oncology

– Other

– Over the counter

– Pain

– Respiratory and inflammatory diseases

– Rheumatology

– Urology

The company also produces a broad range of over-the-counter products, among them Allegra, IcyHot for muscle pain, Gold Bond for skin irritation, and Selsun Blue dandruff shampoo. These brands were acquired in 2010, when Sanofi-Aventis purchased Chattem.

Pipeline

, Sanofi was in a race with Amgen and Pfizer to win approval for a drug that inhibits PCSK9, a protein that slows the clearance of low-density lipoprotein (LDL) cholesterol – the form of cholesterol that leads to heart attacks.[124] Sanofi's drug, a monoclonal antibody, was discovered by Regeneron Pharmaceuticals and is called alirocumab.[125] An FDA warning in March 2014, about possible cognitive adverse effects of PCSK9 inhibition threw the competition into disarray, as the FDA asked companies to include neurocognitive testing into their Phase III clinical trials.[126]

In 2013, Sanofi announced that another candidate from its collaboration with Regeneron, a monoclonal antibody against the interleukin 6 receptor, sarilumab, had better efficacy than placebo in its first Phase III trial in rheumatoid arthritis.[127]

Management

Stockholders

As of 31 December 2013:[132]

Head office

In January 2012, Sanofi moved its head office location to 54, Rue La Boétie in the 8th arrondissement of Paris. This former mansion designed by architect René-Patouillard had previously been the head office of Alcatel-Lucent.

Sanofi's previous head office was located in the 13th arrondissement of Paris, at 174 Avenue de France. The architecture of the head office is of the predominant style of the area surrounding the François Mitterrand Library. After Sanofi and Aventis merged, the employees at the former Aventis head office in Schiltigheim, Alsace, moved to Paris.[133]

In November 2022, Sanofi moved into its new global headquarters in the 17th arrondissement of Paris, at 46-48 Avenue de la Grande Armée.[134] [135]

Collaborative research

In addition to internal research and development activities, Sanofi is also involved in publicly funded collaborative research projects, with other industrial and academic partners. One example in the area of non-clinical safety assessment is the InnoMed PredTox project[136] [137] The company is expanding its activities in joint research projects within the framework of the Innovative Medicines Initiative of EFPIA and the European Commission.[138]

In June 2010, Sanofi and the Charité University of Berlin signed a cooperation agreement for the research and development of medicines and therapies.[139]

On 25 October 2012, Sanofi said its earnings for the third quarter slumped, as generic competitors ate into profits from its Eloxatin cancer treatment.[140]

Sanofi Pasteur

See main article: Sanofi Pasteur.

In 2005, Sanofi Pasteur, the vaccines division of Sanofi Group, was awarded a $97 Million United States Department of Health and Human Services (HHS) contract.[141]

BCG supply shortage 2012-

In 2011, a Sanofi Pasteur plant flooded, causing it problems with mold. The facility, located in Toronto, Ontario, Canada, produced BCG vaccine products, made with the Glaxo 1077 strain,[142] such as a tuberculosis vaccine ImmuCYST, a BCG Immunotherapeutic, a bladder cancer drug. By April 2012, the FDA had found dozens of documented problems with sterility at the plant, including mold, nesting birds, and rusted electrical conduits. The plant was closed for over two years, resulting in shortages of bladder cancer and tuberculosis vaccines. On 29 October 2014 Health Canada gave Sanofi permission to resume production of BCG.

COVID-19 vaccine

See main article: article, Sanofi–GSK COVID-19 vaccine and Sanofi–Translate Bio COVID-19 vaccine. In 2020, Sanofi, together with GSK, signed a deal with the US government's Operation Warp Speed to provide 100 million doses of COVID-19 vaccine for up to US$2.1 billion, if the vaccine was approved.

As of August 2020, COVID-19 vaccine development in Sanofi underscored its fundamental competitiveness weakness, with which management has been struggling and failed to deal with for many years, beyond cutting more costs. Unfortunately, even though the approach of Sanofi-GSK is based on pre-existing, approved platforms and technology (as with Flublok flu), without reinventing the wheel of the necessary infrastructure, the company lagged behind many other rivals in delivering a working vaccine. Sanofi planned to start Phase 1 clinical testing only in September and expected emergency use approval in the first half of 2021. Competitors such as Novavax had already completed Phase 1 studies, with promising results, and Moderna-NIH had already initiated its Phase 3 trial. According to CNBC reports, as part of the $2.1 billion US government deal, more than 750 million went to supporting Sanofi-GSK in vaccine development and clinical trials. Sanofi turn-outs "accelerate" the development via a smaller biotech firm, Translate Bio, with a $425M partnership.

At the end of September 2021, Sanofi announced that it would stop developing its mRNA COVID-19 vaccine. Despite promising results, the drug would not continue to Phase 3 trials, and the company stated that it would be 'too late to reach the market.'[143] [144]

Associations

Sanofi is a full member of the European Federation of Pharmaceutical Industries and Associations (EFPIA),[145] the Biotechnology Industry Organization (BIO),[146] and the Pharmaceutical Research and Manufacturers of America (PhRMA).[147]

Sanofi's vaccine subsidiary, Sanofi Pasteur, is a member of EuropaBio.[148]

In June 2021, Sanofi partnered with Capgemini, Orange & Generali to launch Future4care, an all-European start-up accelerator centered on digital health.[149] [150]

Aventis Foundation

The Aventis Foundation, a German charitable trust, was established in 1996, as the Hoechst Foundation, with an endowment of €50 million. In 2000, the foundation was renamed the Aventis Foundation. The foundation promotes cultural and scientific projects, specifically focused on the Frankfurt Rhine-Main area.[151]

See also

Notes and References

  1. Web site: Annual Report 2023 (Form 20-F) . 2024-02-23 . U.S. Securities and Exchange Commission.
  2. Web site: Börse Frankfurt (Frankfurt Stock Exchange): Stock market quotes, charts and news . dead . https://web.archive.org/web/20190208093448/http://www.boerse-frankfurt.de/en/equities/indices/euro%20stoxx%2050%20EU0009658145/constituents . 8 February 2019 . 23 May 2017 . boerse-frankfurt.de.
  3. Web site: en. The Global 2000 2023. Forbes. 2024-02-07. 2024-01-29. https://web.archive.org/web/20240129031905/https://www.forbes.com/lists/global2000/?sh=4f5ab07e5ac0.
  4. News: 23 November 2007 . Sanofi-Aventis to sign deal to build flu vaccine plant in China – source . . 2009-04-19.
  5. Web site: 2012-12-28 . Le fondateur de Sanofi est mort . 4 June 2015 . lexpress.fr.
  6. Book: CPE. Chemical & Process Engineering . 1964 . L. Hill . 83.
  7. Book: Sneader, Walter . Drug discovery: the evolution of modern medicines . 1985-09-13 . Wiley . 9780471904717.
  8. Staff, The Pharma Letter. Sept 20, 1993 Sanofi Extends Holding in Chinoin
  9. http://www.securities.com/php/company-profile/HU/Chinoin_Zrt_en_1441051.html Chinoin listing in at securities.com
  10. Collins . Joseph C. . Gwilt . John R. . 2000 . The Life Cycle of Sterling Drug, Inc. . . 25 . 1 . 22–27.
  11. Sanofi-Synthélabo Form 20F for the Fiscal Year ended 31 December 2002
  12. Denis Cosnard for Les Echos. 11 December 1991. Synthélabo s'offre Delalande
  13. Denis Conard for Les Echos. 17 October 1991 Synthélabo rachète les laboratoires Delagrange
  14. Bibliothèque nationale de France Laboratoires Delagrange Page accessed 24 August 2016
  15. Tom Meek for PMLiVE 24 May 2013 A look back at Sanofi's merger with Synthélabo
  16. Joseph Borkin: The Crime and Punishment of I.G. Farben (New York: The Free Press, 1990), p. 163.
  17. Aventis Form 20-F for the fiscal year ended 31 December 2002
  18. Arturo Bris and Christos Cabolis,Corporate Governance Convergence Through Cross-Border Mergers The Case of Aventis, Chapter 4 in Corporate Governance and Regulatory Impact on Mergers and Acquisitions: Research and Analysis on Activity Worldwide Since 1990. Eds Greg N. Gregoriou, Luc Renneboog. Academic Press, 26 July 2007
  19. Lawton Robert Burns The Business of Healthcare Innovation Cambridge University Press, 26 July 2012
  20. News: Meier . Barry . 1996-06-11 . Blood, Money and AIDS: Haemophiliacs Are Split; Liability Cases Bogged Down in Disputes . .
  21. News: Pollack . Andrew . 24 June 2000 . Aventis Unit Sets Big Investment in Biotechnology Start-Up . . 27 November 2019.
  22. News: 16 November 2000 . Aventis to Sell Agriculture Unit . . Bloomberg News . 27 November 2019.
  23. CNN Money. 2 October 2001 Bayer buys CropScience
  24. Candace Hoffmann for First Word Pharma. 8 September 2003 Aventis inks deal with Regeneron for collaboration on cancer therapy
  25. Web site: Gever . John . 19 November 2011 . FDA Approves Eylea for Macular Degeneration . 2013-10-16 . MedpageToday.com.
  26. Ciombor KK . etal . 2013 . Aflibercept . Clin Cancer Res . 19 . 8 . 1920–1925 . 10.1158/1078-0432.CCR-12-2911 . 3710732 . 23444216.
  27. Web site: 13 February 2018 . 2012 Notifications . live . https://web.archive.org/web/20191226010037/https://www.fda.gov/drugs/resources-information-approved-drugs/2012-notifications . 26 December 2019 . 25 December 2019 . U.S. Food and Drug Administration (FDA).
  28. News: Timmons . Heather . 3 April 2004 . Aventis Invites Novartis To Counter Sanofi's Bid . . 27 November 2019.
  29. News: Timmons . Heather . 27 April 2004 . France Helped Broker the Aventis-Sanofi Deal . . 27 November 2019.
  30. News: 24 April 2004 . Aventis Plan Is Rejected . . Bloomberg News . 27 November 2019.
  31. Kimberly S Cleaves and Ann M Thayer Warning, merge with care: Sanofi-Aventis Modern Drug Discovery, August 2004:21-26
  32. News: Zielbauer . Paul von . 4 September 2006 . Iraqis Infected by H.I.V.-Tainted Blood Try New Tool: A Lawsuit . . 27 November 2019.
  33. BMS Press Release. 8 December 2006 Preliminary Injunction Against Apotex Upheld on Appeal
  34. Aaron Smith for CNNMoney.com 26 October 2006 Bristol CEO Dolan gets fired: Company says it heeded request of a federal monitor
  35. Donald Zuhn for Patent Docs. 9 November 2011 Sanofi-Aventis v. Apotex Inc. (Fed. Cir. 2011)
  36. Linda a. Johnson for Associated Press 8 February 2012 Apotex pays Bristol, Sanofi damages over Plavix
  37. Carolina Bolado for Law360 14 March 2013. Bristol-Myers Escapes $3.4B Apotex Suit Over Plavix Deal
  38. News: Winslow . Ron . 10 November 2009 . Sanofi Expands Regeneron Deal . . 27 November 2019.
  39. Genetic Engineering and Biotechnology News. 11 November 2009 Sanofi-Aventis Commits Over $2.8B to Regeneron in mAb Discovery Alliance
  40. FierceBiotech. Sanofi-Aventis: A timeline of biopharma deals
  41. Andy Tisman for IMS Health 2010 The Rising Tide of OTC in Europe
  42. News: 22 September 2008 . Sanofi-Aventis to buy Czech generic drug maker . . 27 November 2019.
  43. Leigh Kamping-Carder for Law360. 20 May 2010 Brazil Clears Sanofi's $635M Medley Pharma Buy
  44. Gareth Macdonald for PharmaTechnologist, 15 April 2009 Sanofi beats Teva in Medley melee
  45. Web site: Sanofi snaps up India's Shantha for $784M . FierceBiotech. 27 July 2009 .
  46. News: Gryta . Thomas . Spencer . Mimosa . 9 October 2010 . Sanofi Cuts Jobs, Counters Genzyme . . 27 November 2019.
  47. News: 21 December 2009 . Drug Maker Sanofi-Aventis Buys Chattem for $1.9 Billion . . Reuters. 27 November 2019.
  48. Phil Serafino for Bloomberg News. 28 October 2010 Sanofi-Aventis to Buy BMP Sunstone to Expand in China
  49. News: Mennella . Noelle . 6 May 2011 . Sanofi changes name, pace of acquisitions to slow . . 7 May 2011.
  50. News: Nicholson . Chris V. . 16 February 2011 . Sanofi Agrees to Buy Genzyme for $20.1 Billion . . 27 November 2019.
  51. News: Weintraub . Arlene . 10 January 2012 . Warp Drive Bio Launches With $125M from Third Rock, Greylock, Sanofi . Xconomy . 6 April 2014 . 7 April 2014 . https://web.archive.org/web/20140407111220/http://www.xconomy.com/boston/2012/01/10/warp-drive-bio-launches-with-125m-from-third-rock-greylock-sanofi/?single_page=true . dead .
  52. Web site: TTR Amyloidosis (FAP) . Alnylam Pharmaceuticals . 13 April 2014 . 14 April 2014 . https://web.archive.org/web/20140414172941/http://www.alnylam.com/product-pipeline/ttr-amyloidosis-fap/ . dead .
  53. News: Bray . Chad . 13 January 2014 . Sanofi Unit to Buy $700 Million Stake in Rare Disease Company . . 27 November 2019.
  54. News: Baigorri . Manuel . Torsoli . Albertina . Welch . David . 25 March 2014 . Sanofi Said to Join Bidders for Merck's Consumer-Health Unit . Bloomberg News . en.
  55. News: Huet . Natalie . Mennella . Noëlle . 29 October 2014 . French drugmaker Sanofi sacks CEO, shares drop . 6 July 2015 . Reuters .
  56. Sanofi Appoints Olivier Brandicourt as Chief Executive Officer . February 19, 2015 . Sanofi . https://web.archive.org/web/20150425041931/http://en.sanofi.com/NasdaQ_OMX/LOCAL/press_releases/sanofi___sanofi_appoints_olivi_1896027_19-02-2015!22_45_00.aspx . 2015-04-25.
  57. News: Silverman . Ed . 24 February 2015 . French Government Slams Sanofi Over Brandicourt Pay Package . . 6 July 2015.
  58. Web site: Eric Palmer . 2014-06-26 . Sanofi buys Dubai's Globalpharma to produce generics in the Middle East . 2017-02-24 . Questex LLC..
  59. Web site: 2015-07-27 . Genzyme to Buy Caprelsa from AstraZeneca for Up to $300M - GEN News Highlights - GEN . Genengnews.com.
  60. Web site: 2015-07-28 . Regeneron, Sanofi Launch $2B+ Immuno-Oncology Collaboration - GEN News Highlights - GEN . Genengnews.com.
  61. Web site: UPDATED: Struggling Sanofi paying $1.8B to partner with Regeneron on immuno-oncology . FierceBiotech.com. 28 July 2015 .
  62. Web site: Aiming for top dog status, Sanofi and Boehringer swap animal and consumer health units . FiercePharma.com. 27 June 2016 .
  63. Web site: Sanofi – Sanofi to acquire Protein Sciences – Sanofi . mediaroom.sanofi.com . 12 July 2017 . 15 July 2017 . https://web.archive.org/web/20170715092729/http://mediaroom.sanofi.com/sanofi-to-acquire-protein-sciences/ . dead .
  64. News: Hirschler . Ben . 2018-01-22 . Biotech M&A takes off as Sanofi and Celgene spend $20 billion . Reuters.
  65. News: Blamont . Matthias . 2018-01-30 . Sanofi beats Novo to buy Ablynx for $4.8 billion in biotech M&A boom . Reuters.
  66. Web site: Sanofi: Press Releases, Monday, December 9, 2019 . 11 December 2020 . sanofi.com/en . 3 February 2021 . https://web.archive.org/web/20210203235720/https://www.sanofi.com/media-room/press-releases/2019/2019-12-09%2007-00-00%201957603 . dead .
  67. Web site: Sanofi Pushes Further into Immuno-Oncology with $2.5 Billion Synthorx Takeover . 11 December 2020 . BioSpace.
  68. Web site: Taylor . Nick Paul . 2022-10-28 . In wake of bempeg blowup, Sanofi rethinks $2.5B bet on IL-2 after midphase efficacy falls short . 2022-10-31 . Fierce Biotech . en.
  69. Web site: Sanofi reveals setback for cancer drug acquired in Synthorx buyout . 2022-10-31 . BioPharma Dive . en-US.
  70. Sanofi . 2022-10-05 . A Phase 1/2 Non-randomized, Open-label, Multi-cohort, Multi-center Study Assessing the Clinical Benefit of SAR444245 (THOR- 707) Combined With Cemiplimab for the Treatment of Participants With Advanced Unresectable or Metastatic Skin Cancers .
  71. News: 25 May 2020 . U.S.' Regeneron to buy back $5 billion stake held by Sanofi . Reuters. 11 December 2020.
  72. News: Mishra . Sudip Kar-Gupta, Manas . 23 June 2020 . Sanofi clinches $2 billion vaccines deal with Translate Bio . Reuters. 11 December 2020 . uk.reuters.com.
  73. News: 29 July 2020 . Coronavirus vaccine: UK signs deal with GSK and Sanofi . BBC News . 11 December 2020 .
  74. Web site: U.S. agrees to pay Sanofi and GSK $2.1 billion for 100 million doses of coronavirus vaccine . 31 July 2020 . CNBC.
  75. Web site: Sanofi Acquires Principia Biopharma in $3.6 Billion Deal . 11 December 2020 . BioSpace.
  76. Web site: Sanofi to acquire Principia Biopharma . 11 December 2020 . BioSpace.
  77. News: Kar-Gupta . Sudip . 17 August 2020 . Sanofi in hunt for specialty drugs with $3.7 billion deal for U.S.-based Principia . Reuters. 11 December 2020 . uk.reuters.com.
  78. Web site: 2020-09-29 . Sanofi concludes acquisition of Principia Biopharma . 2020-09-29 . Express Pharma . en-US.
  79. Web site: Sanofi Picks Up Kiadis and Its Immuno-Oncology Assets for $359 Million . 11 December 2020 . BioSpace.
  80. News: White. Sarah. 2021-01-11. Sanofi buys Kymab for up to $1.5 billion to expand in immunotherapy. en. Reuters. 2021-01-11.
  81. Sanofi to acquire Kymab, adding KY1005 to its pipeline, a human monoclonal antibody targeting key immune system regulator OX40L. 11 January 2021.
  82. Web site: Sanofi Ups Immunology Game with $1.4 Billion Acquisition of Kymab.
  83. Web site: Sanofi Snatches up Tidal Therapeutics in $470 Million Deal.
  84. News: EXCLUSIVE Sanofi offers to buy U.S. Biotech, mRNA partner Translate Bio -sources. Reuters. 3 August 2021. Blamont. Matthias.
  85. News: France's Sanofi to buy U.S. biopharma firm Kadmon in $1.9 bln deal. Reuters. 2021-09-08. 2021-09-08.
  86. Web site: Rosemain. Mathieu. Drugmaker Sanofi invests $180 million in French AI startup Owkin - Metro US. 2021-11-18. metro.us. 18 November 2021 . en-US.
  87. Web site: Sanofi to acquire Origimm Biotechnology in first move to treat acne with vaccine-based immunotherapy. BioSpace.
  88. News: Sanofi to buy Origimm Biotechnology for acne vaccine candidate. 1 December 2021. Reuters.
  89. News: Sanofi in $1 bln deal to buy U.S.-based Amunix Pharma. Reuters. 21 December 2021.
  90. Web site: Sanofi in $1 bln deal to buy U.S.-based Amunix Pharma . Joyce . Teo. The Straits Times. 2022-04-20. 2022-04-30.
  91. News: Sanofi hones in on type 1 diabetes in $2.9 BLN Provention Bio deal . Reuters . 13 March 2023 . Burger . Ludwig . Kartit . Dina .
  92. Web site: en. Sanofi's planned consumer health spinoff picks up interest from multiple firms: Bloomberg. Fierce Pharma. 2024-02-27. 2024-02-21. https://web.archive.org/web/20240221163740/https://www.fiercepharma.com/pharma/sanofis-planned-consumer-health-spinout-picks-interest-top-firms-bloomberg.
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  94. Web site: Sanofi Buys Inhibrx for Up to $2.2B to Bolster Inflammation Drug Pipeline . 2024-01-24 . BioSpace . en-US.
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  96. Web site: 2011-03-01 . Annual Report 2010 on SEC Filing Form 20-F . 2017-02-22 . Sanofi.
  97. Web site: 2016-03-04 . Annual Report 2015 on SEC Filing Form 20-F . 2017-02-22 . Sanofi.
  98. Web site: 2019-03-08 . Form 20-F 2016 . 27 November 2019 . EDGAR.
  99. Web site: 2 March 2018 . Form 20-F 2017 . 27 November 2019 . EDGAR.
  100. Web site: 2019-03-08 . Form 20-F 2018 . 27 November 2019 . EDGAR.
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  102. Web site: Sanofi Buys Inhibrx for Up to $2.2B to Bolster Inflammation Drug Pipeline . 2024-01-24 . BioSpace . en-US.
  103. FDA approves new multiple sclerosis treatment Aubagio . 12 September 2012 . U.S. Food and Drug Administration (FDA) . 2012-09-14 . https://web.archive.org/web/20120913084145/https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm319277.htm . 13 September 2012 . dead.
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  105. News: Thomas . Katie . 1 February 2013 . Brothers Develop New Device to Halt Allergy Attacks . . 27 November 2019.
  106. Web site: All Allerject epinephrine auto-injectors recalled . Cbc.ca.
  107. Web site: Sanofi Canada Issues Voluntary Nationwide Recall of Allerject Due to Potential Inaccurate Dosage Delivery . 22 September 2018 . Allerject.ca.
  108. Web site: Auvi-Q® (epinephrine injection, USP) . Auvi-q.com.
  109. Web site: 30 October 2015 . UPDATED: Sanofi US Issues Voluntary Nationwide Recall of All Auvi-Q Due to Potential Inaccurate Dosage Delivery . dead . https://web.archive.org/web/20170203141137/https://www.fda.gov/Safety/Recalls/ucm469980.htm . 3 February 2017 . 23 May 2017 . U.S. Food and Drug Administration (FDA).
  110. Web site: Sanofi Canada Issues Voluntary Nationwide Recall of Allerject® Due to Potential Inaccurate Dosage . Newswire.ca.
  111. Web site: 2015-10-29 . Sanofi US Issues Voluntary Nationwide Recall of ALL Auvi‑Q Epi Pens - Children's Medical Center . 2024-08-08 . en-US.
  112. Web site: 2015-03-19 . Welcome to EpiPen® 101 . Epipen101.ca.
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  115. Web site: It's open season for Mylan's EpiPen as Sanofi, Teva stumble – FiercePharma . Fiercepharma.com. 2 November 2015 .
  116. Lisa M. Jarvis for Chemical and Engineering News. 14 January 2008 Isis, Genzyme In Heart Drug Deal
  117. News: 29 January 2013 . F.D.A. Approves Genetic Drug to Treat Rare Disease . . 27 November 2019.
  118. Web site: Annual Review 2008 . 2009-04-19 . Sanofi-Aventis.
  119. Mozobil approved for non-hodgkin's lymphoma and multiple myeloma . 18 December 2008 . Monthly Prescribing Reference . 3 January 2009.
  120. Mozobil approved for non-Hodgkin's lymphoma and multiple myeloma . 18 December 2008 . Monthly Prescribing Reference . 3 January 2009.
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  123. Web site: Cough Medicine UAE - Eliminate Excess Mucus & Phlegm | Mucosolvan. Cough And Cold Medicine To Eliminate Mucus | Mucosolvan®.
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  126. John Carroll for FierceBiotech 7 March 2014 UPDATED: Regeneron, Sanofi and Amgen shares suffer on FDA's frets about PCSK9 class
  127. John Carroll for FierceBiotech 22 November 2013 Regeneron, Sanofi hit a trio of goals in first PhIII test of rheumatoid arthritis drug
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  131. Web site: 2 February 2024. Sanofi recruits François-Xavier Roger .
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  141. Web site: 4 January 2005 . Sanofi pasteur Awarded $97 Million HHS Contract to Accelerate Cell-Culture Pandemic Influenza Vaccine Development . dead . https://web.archive.org/web/20050425220406/http://www.presseportal.de/story.htx?nr=664301&ressort=7 . 25 April 2005 . 12 June 2013.
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  143. Web site: 2021-09-28. France's Sanofi halts work on mRNA Covid vaccine amid success of Pfizer, Moderna. 2021-09-29. France 24. en.
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  149. Web site: Tazrout. Zacharie. Orange, Generali, Sanofi and Capgemini launch Future4care, a start-up accelerator. 2021-07-07. Actu IA. 11 June 2021 . fr-FR.
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