Sanjiv Sam Gambhir Explained
Sanjiv Sam Gambhir |
Birth Date: | 23 November 1962 |
Birth Place: | Ambala, Haryana, India |
Nationality: | American |
Fields: | Nuclear Medicine, Radiology, and Bioengineering |
Workplaces: | Stanford University |
Alma Mater: | Arizona State University (B.S.), University of California, Los Angeles (M.D. & Ph.D.) |
Academic Advisors: | M.E. Phelps, S.C. Huang, and H.R. Herschman |
Known For: | Molecular Imaging, Nuclear Medicine, PET-CT, and Early Cancer Detection |
Awards: | Institute of Medicine (IOM) of the US National Academies (2008)American Association for the Advancement of Science (2014)National Academy of Inventors (2015) |
Sanjiv Sam Gambhir (November 23, 1962 – July 18, 2020) was an American physician–scientist. He was the Virginia and D.K. Ludwig Professor in Cancer Research,[1] Chairman of the Department of Radiology[2] at Stanford University School of Medicine, and a professor by courtesy in the departments of Bioengineering and Materials Science and Engineering at Stanford University. Additionally, he served as the Director of the Molecular Imaging Program at Stanford (MIPS),[3] Canary Center at Stanford for Cancer Early Detection[4] and the Precision Health and Integrated Diagnostics Center (PHIND).[5] He authored 680 publications and had over 40 patents pending or granted.[6] His work was featured on the cover of over 25 journals including the Nature Series, Science, and Science Translational Medicine. He was on the editorial board of several journals including Nano Letters, Nature Clinical Practice Oncology, and Science Translational Medicine. He was founder/co-founder of several biotechnology companies and also served on the scientific advisory board of multiple companies. He mentored over 150 post-doctoral fellows and graduate students from over a dozen disciplines. He was known for his work in molecular imaging of living subjects and early cancer detection.
Personal
Gambhir was born in Ambala, India, and moved to the US with his parents and sister in 1969. He was raised in Phoenix, Arizona. He was married to Aruna Bodapati Gambhir and lived in the Bay Area. He died July 18, 2020, of cancer of unknown primary. His son, Milan Gambhir, was born in 1998 and died from a glioblastoma[7] in 2015.
Education and employment
Gambhir was a Phi Beta Kappa graduate of Arizona State University where he received his BS in physics. He then entered the combined MD–PhD Medical Scientist Training Program (MSTP) at the University of California Los Angeles (UCLA) and received his MD, and his PhD in biomathematics.[8]
His first academic appointment was in 1994, at UCLA, as an assistant professor of molecular and medical pharmacology. He was a clinical attending in the Nuclear Medicine Department at the Center for Health Sciences at UCLA starting in 1997. He was appointed tenure professorship at UCLA in 2003.[9] In 2003, he moved to Stanford University and was appointed professor of radiology, head of nuclear medicine, director of the Molecular Imaging Program at Stanford (MIPS), director of the Precision Health and Integrated Diagnostics (PHIND) Center,[10] division chief of the Canary Center for Cancer Early Detection, and member of the Bio-X Program. He became the Virginia and D.K. Ludwig Professor for Clinical Investigation in Cancer Research, which is an endowed professorship, in 2009. He was appointed the chair of radiology in August 2011.[8] [11]
Honors and awards
Gambhir received the following:
- Taplin Award[12]
- Holst Medal[13]
- Academy of Molecular Imaging (AMI) Distinguished Basic Scientist of the Year Award[14]
- Society for Molecular Imaging (SMI) Achievement Award[15]
- Distinguished Clinical Scientist Award from the Doris Duke Charitable Foundation[16]
- Hounsfield Medal (Imperial College London)[17]
- Fellowship of the American Institute for Medical and Biological Engineering (AIMBE)[18]
- Paul C. Aebersold Award[19]
- Organizer and co-chair for the Nobel Symposium in Imaging (2008)
- Inducted as a member of the American Society for Clinical Investigation (ASCI)[20]
- Tesla Medal
- Elected to the Institute of Medicine (IOM) of the US National Academies[21]
- Parmley Prize
- Radiological Society of North America (RSNA)
- Outstanding Researcher Award[22]
- Gopal Subramanian Lifetime Achievement Award[23]
- George Charles de Hevesy Nuclear Pioneer Award[24]
- Aunt Minnie Award[25]
- Distinguished Scientist Award for Distinguished Contributions to Nuclear Medicine[26]
- Society of Asian American Scientists in Cancer Research Award[27]
- American Association of Indian Scientists in Cancer Research Lifetime Achievement Award[28]
- American Association for the Advancement of Science (AAAS) Fellow Award[29]
- J. Allyn Taylor International Prize in Medicine[30]
- National Academy of Inventors[31]
- American Association for the Advancement of Science[32]
- Basic Science Teaching Award
- Benedict Cassen Prize for Research in Molecular Imaging[33]
- Institute of Electrical and Electronics Engineers (IEEE) Marie Sklodowska-Curie Award - IEEE Advancing Technology for Humanity[34]
Research focus
His research focused on the development of imaging assays to monitor fundamental cellular/molecular events in living subjects with an emphasis on the detection and management of cancer. A particular interest of his research and lab was early cancer detection including combining in vivo and in vitro diagnostics.
Major contributions
PET reporter gene technology, multimodality reporter genes, imaging of gene/cell therapies, imaging of the immune system, imaging of intracellular events in living subjects (e.g., protein-protein interactions), bioluminescence resonance energy transfer (BRET) in living subjects, nanoparticle based imaging, Raman imaging in vivo and photoacoustic molecular imaging with novel imaging agents in living subjects. Decision Management Models for the use of FDG PET in cancer.
Selected publications
- 7377213. 2020 . Park . S. M. . Won . D. D. . Lee . B. J. . Escobedo . D. . Esteva . A. . Aalipour . A. . Ge . T. J. . Kim . J. H. . Suh . S. . Choi . E. H. . Lozano . A. X. . Yao . C. . Bodapati . S. . Achterberg . F. B. . Kim . J. . Park . H. . Choi . Y. . Kim . W. J. . Yu . J. H. . Bhatt . A. M. . Lee . J. K. . Spitler . R. . Wang . S. X. . Gambhir . S. S. . A mountable toilet system for personalized health monitoring via the analysis of excreta . Nature Biomedical Engineering . 4 . 6 . 624–635 . 10.1038/s41551-020-0534-9 . 32251391 .
- 6561252. 2019 . Haywood . T. . Beinat . C. . Gowrishankar . G. . Patel . C. B. . Alam . I. S. . Murty . S. . Gambhir . S. S. . Positron emission tomography reporter gene strategy for use in the central nervous system . Proceedings of the National Academy of Sciences of the United States of America . 116 . 23 . 11402–11407 . 10.1073/pnas.1901645116 . 31123153 . 2019PNAS..11611402H . free .
- 30886438 . 10.1038/s41587-019-0064-8 . 37 . 5 . Engineered immune cells as highly sensitive cancer diagnostics . 2019 . Aalipour A, Chuang HY, Murty S, D'Souza AL, Park SM, Gulati GS, Patel CB, Beinat C, Simonetta F, Martinić I, Gowrishankar G, Robinson ER, Aalipour E, Zhian Z, Gambhir SS . Nat Biotechnol . 531–539. 7295609 .
- Vermesh O., Aalipour A., Ge J., Saenz Y., Guo Y., Park S., Mitsutake Y., Bachmann M., Ooi C.C., Lyons J.K., Mueller K., Arami H., Green A., Wang S.X., Gambhir S.S. . 2018 . An Intravascular Magnetic Wire for High-Throughput In Vivo Enrichment of Rare Circulating Cancer Biomarkers . Nature Biomedical Engineering . 2. 9. 696–705 . 10.1038/s41551-018-0257-3 . 30505627 . 6261517 .
- Mayer A.T., Gambhir S.S. . 2018 . Reply: Optimizing Strategies for Immune Checkpoint Imaging with Immuno-PET in Preclinical Study . Journal of Nuclear Medicine . 59 . 4. 711–712 . 10.2967/jnumed.117.205153 . 29348318 . free .
- 5822551. 2018 . Hoehne . A. . James . M. L. . Alam . I. S. . Ronald . J. A. . Schneider . B. . d'Souza . A. . Witney . T. H. . Andrews . L. E. . Cropper . H. C. . Behera . D. . Gowrishankar . G. . Ding . Z. . Wyss-Coray . T. . Chin . F. T. . Biswal . S. . Gambhir . S. S. . 18FFSPG-PET reveals increased cystine/Glutamate antiporter (Xc-) activity in a mouse model of multiple sclerosis . Journal of Neuroinflammation . 15 . 1 . 55 . 10.1186/s12974-018-1080-1 . 29471880 . free .
- Alam I.S., Mayer A.T., Sagiv-Barfi I, Wang K., Vermesh O., Czerwinski D.K., Johnson E.M., James M.L., Levy R., Gambhir S.S. . 2018 . Imaging Activated T Cells Predicts Response To Cancer Vaccines . Journal of Clinical Investigation . 128 . 6. 2569–2580 . 10.1172/jci98509. 29596062 . 5983309 .
- Sagiv-Barfi I, Czerwinski D.K., Levy S., Alam I.S., Mayer A.T., Gambhir, Levy R. . 2018 . Eradication of Spontaneous Malignancy by Local Immunotherapy . Science Translational Medicine . 10 . 426. 426 . 5997264 . 29386357 . 10.1126/scitranslmed.aan4488.
- Hori, S.S.; A.M. Lutz; R. Paulmurugan; S.S. Gambhir . March 2017. A Model-Based Personalized Cancer Screening Strategy for Early Detection . Nature Biomedical Engineering. 1. 62. 1–3.
- 10.1126/scitranslmed.aag2196. Reporter gene imaging of targeted T cell immunotherapy in recurrent glioma . 2017 . Keu . Khun Visith . Witney . Timothy H. . Yaghoubi . Shahriar . Rosenberg . Jarrett . Kurien . Anita . Magnusson . Rachel . Williams . John . Habte . Frezghi . Wagner . Jamie R. . Forman . Stephen . Brown . Christine . Allen-Auerbach . Martin . Czernin . Johannes . Tang . Winson . Jensen . Michael C. . Badie . Behnam . Gambhir . Sanjiv S. . Science Translational Medicine . 9 . 373 . 28100832 . 5260938 .
- 10.1073/pnas.1608461113. Molecular profiling of single circulating tumor cells from lung cancer patients . 2016 . Park . Seung-min . Wong . Dawson J. . Ooi . Chin Chun . Kurtz . David M. . Vermesh . Ophir . Aalipour . Amin . Suh . Susie . Pian . Kelsey L. . Chabon . Jacob J. . Lee . Sang Hun . Jamali . Mehran . Say . Carmen . Carter . Justin N. . Lee . Luke P. . Luke Pyungse Lee . Kuschner . Ware G. . Schwartz . Erich J. . Shrager . Joseph B. . Neal . Joel W. . Wakelee . Heather A. . Diehn . Maximilian . Nair . Viswam S. . Wang . Shan X. . Gambhir . Sanjiv S. . Proceedings of the National Academy of Sciences . 113 . 52 . E8379–E8386 . 27956614 . 5206556 . 2016PNAS..113E8379P . free .
- 27605550 . 10.1126/scitranslmed.aaf3936 . 8 . 355 . [Imaging approaches to optimize molecular therapies]. Weissleder R, Schwaiger MC, Gambhir SS, Hricak H. . Science Translational Medicine . 355ps16 . 2016. 4588770 . .
- 4664306. 2015 . Maute . R. L. . Gordon . S. R. . Mayer . A. T. . McCracken . M. N. . Natarajan . A. . Ring . N. G. . Kimura . R. . Tsai . J. M. . Manglik . A. . Kruse . A. C. . Gambhir . S. S. . Weissman . I. L. . Ring . A. M. . Engineering high-affinity PD-1 variants for optimized immunotherapy and immuno-PET imaging . Proceedings of the National Academy of Sciences of the United States of America . 112 . 47 . E6506–E6514 . 10.1073/pnas.1519623112 . 26604307 . 2015PNAS..112E6506M . free .
- 4538635. 2015 . Inci . F. . Filippini . C. . Baday . M. . Ozen . M. O. . Calamak . S. . Durmus . N. G. . Wang . S. . Hanhauser . E. . Hobbs . K. S. . Juillard . F. . Kuang . P. P. . Vetter . M. L. . Carocci . M. . Yamamoto . H. S. . Takagi . Y. . Yildiz . U. H. . Akin . D. . Wesemann . D. R. . Singhal . A. . Yang . P. L. . Nibert . M. L. . Fichorova . R. N. . Lau . D. T. . Henrich . T. J. . Kaye . K. M. . Schachter . S. C. . Kuritzkes . D. R. . Steinmetz . L. M. . Gambhir . S. S. . Davis . R. W. . Multitarget, quantitative nanoplasmonic electrical field-enhanced resonating device (NE2RD) for diagnostics . Proceedings of the National Academy of Sciences of the United States of America . 112 . 32 . E4354–E4363 . 10.1073/pnas.1510824112 . 26195743 . 2015PNAS..112E4354I . 1 . free .
- Witney T.H. . James M.L. . Shen B. . Chang E. . Pohling C. . Arksey N. . Hoehne A. . Shuhendler A. . Park J.H. . Bodapati D. . Weber J. . Gowrishankar G. . Rao J. . Chin F.T. . Gambhir S.S. . PET Imaging of Tumor Glycolysis Downstream of Hexokinase Through Noninvasive Measurement of Pyruvate Kinase M2 . Science Translational Medicine . 7 . 310. 310 . 10.1126/scitranslmed.aac6117 . 26491079 . Oct 2015. 206688547 . free .
- Ronald J.A. . Chuang H.Y. . Dragulescu-Andrasi A. . Hori S.S. . Gambhir S.S. . 2015. Detecting Cancers Through Tumor-Activatable Minicircles That Lead to a Detectable Blood Biomarker . PNAS USA . 112 . 10. 3068–73 . 10.1073/pnas.1414156112. 4364239 . 25713388. 2015PNAS..112.3068R . free .
- Pan Y. . Volkmer J.P. . Mach K.E. . Rouse R.V. . Sahoo D. . Chang T.C. . Metzner T.J. . de Rijn M. . Skinner E.C . Gambhir S.S. . Weissman I.L. . Liao J.C. . 2014 . Endoscopic Molecular Imaging of Human Bladder Cancer Using a CD47 Antibody . Science Translational Medicine . 6 . 260. 260 . 10.1126/scitranslmed.3009457 . 25355698 . 18276055 .
- Smith. B.R. . E.E.B Ghosn . H. Rallapalli . J.A. Prescher . T. Larson . L.A. Herzenberg . S.S. Gambhir. Selective uptake of single-walled carbon nanotubes by circulating monocytes for enhanced tumor delivery.. Nature Nanotechnology. 2014. 9. 6 . 481–487. 10.1038/nnano.2014.62 . 4236538 . 24727688. 2014NatNa...9..481S .
- Pu. K.. A.J. Shuhendler. J.V. Jokerst. J. Mei. S.S. Gambhir. Z. Bao. J. Rao. Semiconducting Polymer Nanoparticles as Photoacoustic Molecular Imaging Probes in Living Mice.. Nature Nanotechnology. 2014. 9. 3. 233–9. 24463363. 3947658. 10.1038/nnano.2013.302. 2014NatNa...9..233P.
- Bohndiek. S.E.. A. Wagadarikar. C.L. Zavaleta. D. Van de Sompel. E. Garai. J.V. Jokerst. S. Yazdanfar. S.S. Gambhir. A Small Animal Raman Instrument for Rapid, Wide-Area, Spectroscopic Imaging.. PNAS USA. 2013. 110. 30. 12408–13. 23821752. 10.1073/pnas.1301379110. 3725059. 2013PNAS..11012408B. free.
- Zavaleta. C.. E. Garai. J.T. Liu. S. Sensam. M.J. Mandella. D. Van de Sompel. S. Friedland. J. Van Dam. C.H. Contag. S.S. Gambhir. A Raman-Based Endoscopic Strategy for Multiplexed Molecular Imaging.. PNAS USA. 2013. 110. 25. E2288-97. 23703909. 10.1073/pnas.1211309110. 3690865. 2013PNAS..110E2288Z. free.
- Jokerst. J. . C. Khademi . S.S. Gambhir. Intracellular Aggregation of Multimodal Silica Nanoparticles for Ultrasound-Guided Stem Cell Implantation.. Science Translational Medicine. 2013. 5. 177. 177ra35. 10.1126/scitranslmed.3005228. 23515077. 3839309.
- Ziv. K.. S.S. Gambhir. Bioengineering and Regenerative Medicine: Keeping Track.. Nature Materials. 2013. 12. 3. 180–1. 23422714. 10.1038/nmat3579. 2013NatMa..12..180Z.
- Chan. C.T. . R.E. Reeves . R. Geller . S.S. Yaghoubi . A. Hoehne . D.E. Solow-Cordero . G. Chiosis . T.F. Massoud . R. Paulmurugan . S.S. Gambhir. Discovery and Validation of Small-Molecule Heat-Shock Protein 90 Inhibitors Through Multimodality Molecular Imaging in Living Subjects.. PNAS USA. 2012. 109. 37. E2476-85. 22895790. 10.1073/pnas.1205459109. 3443147. free .
- Kircher. M.F.. A. de la Zerda. J.V. Jokerst. C.L. Zavaleta. P.J. Kempson. E. Mittra. R. Huang. C. Campos. F. Habte. R. Sinclair. C.W. Brennan. I.K. Mellinghoff. E.C. Holland. S.S. Gambhir. A Brain Tumor Molecular Imaging Strategy Using a New Triple-Modality MRI-Photoacoustic-Raman Nanoparticle.. Nature Medicine. April 2012. 18. 5. 829–34. 10.1038/nm.2721. 22504484. 3422133.
- 3141927. 2011 . Dragulescu-Andrasi . A. . Chan . C. T. . De . A. . Massoud . T. F. . Gambhir . S. S. . Bioluminescence resonance energy transfer (BRET) imaging of protein–protein interactions within deep tissues of living subjects . Proceedings of the National Academy of Sciences of the United States of America . 108 . 29 . 12060–12065 . 10.1073/pnas.1100923108 . 21730157 . 2011PNAS..10812060D . free .
- 21946842 . 10.1038/nrclinonc.2011.141 . 8 . 11 . Noninvasive cell-tracking methods . 2011 . Kircher MF, Gambhir SS, Grimm J . Nat Rev Clin Oncol . 677–88. 24948508 . ]
- Hori. S.S.. S.S. Gambhir. Mathematical Model Identifies Blood Biomarker-Based Early Cancer Detection Strategies and Limitations.. Science Translational Medicine. November 2011. 3. 109. 109ra116. 22089452. 10.1126/scitranslmed.3003110. 3423335.
- Thakor. A. . R. Luong . R. Paulmurugan . F. Lin . P. Kempen . C. Zavaleta . P. Chu . T.F. Massoud . R. Sinclair . S.S. Gambhir. The Fate and Toxicity of Raman-Active Silica-Gold Nanoparticles in Mice. (Cover Article). Science Translational Medicine. April 2011. 3. 79. 79ra33. 10.1126/scitranslmed.3001963. 21508310. 3873137.
- Dragulescu-Andrasi. A. . C.T. Chan . A. De . T.F. Massoud . S.S. Gambhir. Bioluminescence Resonance Energy Transfer (BRET) Imaging of Protein-Protein Interactions within Deep Tissues of Living Subjects.. PNAS. July 2011. 108. 20. 12060–5. 10.1073/pnas.1100923108. 21730157. 3141927. 2011PNAS..10812060D . free .
- Gaster. R.. D. Hall. C. Nielsen. S. Osterfeld. H. Yu. K. Mach. R. Wilson. B. Murmann. J. Liao. S.S. Gambhir. S. Wang. Matrix-insensitive Protein Assays Push the Limits of Biosensors in Medicine.. Nature Medicine. August 2010. 15. 11. 1327–32. 10.1038/nm.2032. 19820717. 4165514.
- 2936612. 2010 . Fan-Minogue . H. . Cao . Z. . Paulmurugan . R. . Chan . C. T. . Massoud . T. F. . Felsher . D. W. . Gambhir . S. S. . Noninvasive molecular imaging of c-Myc activation in living mice . Proceedings of the National Academy of Sciences of the United States of America . 107 . 36 . 15892–15897 . 10.1073/pnas.1007443107 . 20713710 . free .
- 2964232. 2010 . Liu . H. . Patel . M. R. . Prescher . J. A. . Patsialou . A. . Qian . D. . Lin . J. . Wen . S. . Chang . Y. F. . Bachmann . M. H. . Shimono . Y. . Dalerba . P. . Adorno . M. . Lobo . N. . Bueno . J. . Dirbas . F. M. . Goswami . S. . Somlo . G. . Condeelis . J. . Contag . C. H. . Gambhir . S. S. . Clarke . M. F. . Cancer stem cells from human breast tumors are involved in spontaneous metastases in orthotopic mouse models . Proceedings of the National Academy of Sciences of the United States of America . 107 . 42 . 18115–18120 . 10.1073/pnas.1006732107 . 20921380 . 2010PNAS..10718115L . free .
- Fan-Minogue. H. . Z. Cao . R. Paulmurugan . C.T. Chan . T.F. Massoud . D.W. Felsher . S.S. Gambhir. Noninvasive Molecular Imaging of c-Myc Activation in Living Mice.. PNAS. September 2010. 107. 36. 15892–7. 10.1073/pnas.1007443107. 20713710. 2936612. free .
- Massoud. T. . R. Paulmurugan . S.S. Gambhir. A Molecularly Engineered Split Reporter for Imaging Protein Protein Interactions with Positron Emission Tomography.. Nature Medicine. August 2010. 16. 8. 921–6. 10.1038/nm.2185. 20639890. 2917476.
- Loening, A. Dragulescu-Andrasi, S.S. Gambhir. . A Red-Shifted Renilla Luciferase for Transient Reporter-Gene Expression. . Nature Methods . 7 . 1 . 5–6 . 2010 . 20038949. 10.1038/nmeth0110-05. 4431758 .
- 2749842. 2009 . d'Souza . A. L. . Tseng . J. R. . Pauly . K. B. . Guccione . S. . Rosenberg . J. . Gambhir . S. S. . Glazer . G. M. . A strategy for blood biomarker amplification and localization using ultrasound . Proceedings of the National Academy of Sciences of the United States of America . 106 . 40 . 17152–17157 . 10.1073/pnas.0903437106 . 19805109 . free .
- Zavaleta. C. . B. Smith . I. Wilton . W. Doering . G. Davis . B. Shojaei . M. Natan . S.S. Gambhir. Multiplexed imaging of surface enhanced Raman scattering nanotags in living mice using noninvasive Raman spectroscopy.. PNAS. August 2009. 106. 32. 13511–6. 19666578. 10.1073/pnas.0813327106. 2726370. 2009PNAS..10613511Z . free .
- Yaghoubi . S. . M. Jensen . N. Sastyamurthy . S. Pubhiraja . D. Paik . J. Czernin . S.S. Gambhir . Non-invasive Detection of Therapeutic Cytolytic T-Cells with [18F]-FHBG PET in a Patient with Glioma. . Nature Clinical Practice Oncology . January 2009 . 6 . 1 . 53–8 . 19015650 . 10.1038/ncponc1278 . 3526373.
- D'Souza. A. . J. Tseng . K. Pauly . S. Guccione . J. Rosenberg . S.S. Gambhir . G. Glazer. A Strategy for Blood Biomarker Amplification and Localization using Ultrasound.. PNAS. September 2009. 106. 40. 17152–7. 10.1073/pnas.0903437106. 19805109. 2749842. free .
- Keren. S.. C. Zavaleta. Z. Cheng. A. de la Zerda. O. Gheysens. S.S. Gambhir. Non-invasive Molecular Imaging of Small Living Subjects Using Raman Spectroscopy.. PNAS. April 2008. 105. 15. 5844–49. 18378895. 10.1073/pnas.0710575105. 2299220. 2008PNAS..105.5844K. free.
- Schipper. M. . N. Nakayama-Ratchford . C. Davis . N. Kam . P. Chu . Z. Liu . X. Sun . J. Dai . S.S. Gambhir. A Pilot Toxicology Study of Single-Walled Carbon Nanotubes in a Small Sample of Mice.. Nature Nanotechnology. April 2008. 3. 4. 216–21. 10.1038/nnano.2008.68. 18654506 . 5357814 .
- Willmann. J.. N. van Bruggen. L. Dinkelborg. S.S. Gambhir. Molecular Imaging in Drug Development . Nature Reviews Drug Discovery. July 2008. 7. 7. 591–607. 10.1038/nrd2290. 18591980. 37571813.
- De la Zerda. A.. C. Zavaleta. S. Keren. S. Vaithilingam. S. Bodapati. Z. Liu. J. Levi. B. Smith. T. Ma. O. Oralkan. Z. Cheng. X. Chen. H. Dai. B. Khuri-Yakub. S.S. Gambhir. Carbon Nanotubes as Photoacoustic Molecular Imaging Agents in Living Mice.. Nature Nanotechnology. August 2008. 3. 8. 557–62. 18772918. 10.1038/nnano.2008.231. 2562547. 2008NatNa...3..557D.
- 1544080. 2006 . Lu . Y. . Dang . H. . Middleton . B. . Zhang . Z. . Washburn . L. . Stout . D. B. . Campbell-Thompson . M. . Atkinson . M. A. . Phelps . M. . Gambhir . S. S. . Tian . J. . Kaufman . D. L. . Noninvasive imaging of islet grafts using positron-emission tomography . Proceedings of the National Academy of Sciences of the United States of America . 103 . 30 . 11294–11299 . 10.1073/pnas.0603909103 . 16868090 . 2006PNAS..10311294L . free .
- 16501578 . 10.1038/nbt1188 . 24 . 3 . Self-illuminating quantum dot conjugates for in vivo imaging . 2006 . So MK, Xu C, Loening AM, Gambhir SS, Rao J . Nat Biotechnol . 339–43. 1366622 . ]
- 1635097. 2006 . Paulmurugan . R. . Gambhir . S. S. . An intramolecular folding sensor for imaging estrogen receptor–ligand interactions . Proceedings of the National Academy of Sciences of the United States of America . 103 . 43 . 15883–15888 . 10.1073/pnas.0607385103 . 17043219 . 2006PNAS..10315883P . free .
- 1283986. 2005 . Shu . C. J. . Guo . S. . Kim . Y. J. . Shelly . S. M. . Nijagal . A. . Ray . P. . Gambhir . S. S. . Radu . C. G. . Witte . O. N. . Visualization of a primary anti-tumor immune response by positron emission tomography . Proceedings of the National Academy of Sciences of the United States of America . 102 . 48 . 17412–17417 . 10.1073/pnas.0508698102 . 16293690 . 2005PNAS..10217412S . free .
- 17143277 . 10.1038/nm1458 . 12 . 12 . Quantitative micro positron emission tomography (PET) imaging for the in vivo determination of pancreatic islet graft survival . 2006 . Kim SJ, Doudet DJ, Studenov AR, Nian C, Ruth TJ, Gambhir SS, McIntosh CH . Nat Med . 1423–8. 33430702 .
- Michalet X., Pinaud F.F., Bentolila L.A., Tsay J.M., Doose S., Li J.J., Sundaresan G., Wu A.M., Gambhir S.S., Weiss S. . 2005. Quantum Dots for Live Cells, In Vivo Imaging, and Diagnostics . Science . 307 . 5709. 538–544 . 1201471 . 10.1126/science.1104274 . 15681376. 2005Sci...307..538M.
- 423257. 2004 . Bhaumik . S. . Walls . Z. . Puttaraju . M. . Mitchell . L. G. . Gambhir . S. S. . Molecular imaging of gene expression in living subjects by spliceosome-mediated RNA trans-splicing . Proceedings of the National Academy of Sciences of the United States of America . 101 . 23 . 8693–8698 . 10.1073/pnas.0402772101 . 15161977 . 2004PNAS..101.8693B . free .
- 298756. 2003 . Dubey . P. . Su . H. . Adonai . N. . Du . S. . Rosato . A. . Braun . J. . Gambhir . S. S. . Witte . O. N. . Quantitative imaging of the T cell antitumor response by positron-emission tomography . Proceedings of the National Academy of Sciences of the United States of America . 100 . 3 . 1232–1237 . 10.1073/pnas.0337418100 . 12547911 . 2003PNAS..100.1232D . free .
- 137764. 2002 . Paulmurugan . R. . Umezawa . Y. . Gambhir . S. S. . Noninvasive imaging of protein–protein interactions in living subjects by using reporter protein complementation and reconstitution strategies . Proceedings of the National Academy of Sciences of the United States of America . 99 . 24 . 15608–15613 . 10.1073/pnas.242594299 . 12438689 . 2002PNAS...9915608P . free .
- 122480. 2002 . Ray . P. . Pimenta . H. . Paulmurugan . R. . Berger . F. . Phelps . M. E. . Iyer . M. . Gambhir . S. S. . Noninvasive quantitative imaging of protein–protein interactions in living subjects . Proceedings of the National Academy of Sciences of the United States of America . 99 . 5 . 3105–3110 . 10.1073/pnas.052710999 . 11854471 . 2002PNAS...99.3105R . free .
- 122467. 2002 . Adonai . N. . Nguyen . K. N. . Walsh . J. . Iyer . M. . Toyokuni . T. . Phelps . M. E. . McCarthy . T. . McCarthy . D. W. . Gambhir . S. S. . Gambhir . S. S. . Ex vivo cell labeling with 64Cu–pyruvaldehyde-bis(N4-methylthiosemicarbazone) for imaging cell trafficking in mice with positron-emission tomography . Proceedings of the National Academy of Sciences of the United States of America . 99 . 5 . 3030–3035 . 10.1073/pnas.052709599 . 11867752 . 2002PNAS...99.3030A . free .
- 117568. 2001 . Bhaumik . S. . Gambhir . S. S. . Optical imaging of Renilla luciferase reporter gene expression in living mice . Proceedings of the National Academy of Sciences of the United States of America . 99 . 1 . 377–382 . 10.1073/pnas.012611099 . 11752410 . free .
- 12209157 . 10.1038/nrc882 . 2 . 9 . Molecular imaging of cancer with positron emission tomography . 2002 . Gambhir SS . Nat Rev Cancer . 683–93. 136093076 .
- 12134144 . 10.1038/nm743 . 8 . 8 . Visualization of advanced human prostate cancer lesions in living mice by a targeted gene transfer vector and optical imaging . 2002 . Adams JY, Johnson M, Sato M, Berger F, Gambhir SS, Carey M, Iruela-Arispe ML, Wu L . Nat Med . 891–7. 8378089 .
- 64727. 2001 . Iyer . M. . Wu . L. . Carey . M. . Wang . Y. . Smallwood . A. . Gambhir . S. S. . Two-step transcriptional amplification as a method for imaging reporter gene expression using weak promoters . Proceedings of the National Academy of Sciences of the United States of America . 98 . 25 . 14595–14600 . 10.1073/pnas.251551098 . 11734653 . 2001PNAS...9814595I . free .
- 16007. 2000 . Gambhir . S. S. . Bauer . E. . Black . M. E. . Liang . Q. . Kokoris . M. S. . Barrio . J. R. . Iyer . M. . Namavari . M. . Phelps . M. E. . Herschman . H. R. . A mutant herpes simplex virus type 1 thymidine kinase reporter gene shows improved sensitivity for imaging reporter gene expression with positron emission tomography . Proceedings of the National Academy of Sciences of the United States of America . 97 . 6 . 2785–2790 . 10.1073/pnas.97.6.2785 . 10716999 . 2000PNAS...97.2785G . free .
- 26976. 2000 . Wu . A. M. . Yazaki . P. J. . Tsai . S. W. . Nguyen . K. . Anderson . A. L. . McCarthy . D. W. . Welch . M. J. . Shively . J. E. . Williams . L. E. . Raubitschek . A. A. . Wong . J. Y. . Toyokuni . T. . Phelps . M. E. . Gambhir . S. S. . High-resolution microPET imaging of carcinoembryonic antigen-positive xenografts by using a copper-64-labeled engineered antibody fragment . Proceedings of the National Academy of Sciences of the United States of America . 97 . 15 . 8495–8500 . 10.1073/pnas.150228297 . 10880576 . 2000PNAS...97.8495W . free .
- 10932234 . 10.1038/78704 . 6 . 8 . Quantification of target gene expression by imaging reporter gene expression in living animals . 2000 . Yu Y, Annala AJ, Barrio JR, Toyokuni T, Satyamurthy N, Namavari M, Cherry SR, Phelps ME, Herschman HR, Gambhir SS . Nat Med . 933–7. 42839932 .
- 26784. 1999 . Gambhir . S. S. . Barrio . J. R. . Phelps . M. E. . Iyer . M. . Namavari . M. . Satyamurthy . N. . Wu . L. . Green . L. A. . Bauer . E. . MacLaren . D. C. . Nguyen . K. . Berk . A. J. . Cherry . S. R. . Herschman . H. R. . Imaging adenoviral-directed reporter gene expression in living animals with positron emission tomography . Proceedings of the National Academy of Sciences of the United States of America . 96 . 5 . 2333–2338 . 10.1073/pnas.96.5.2333 . 10051642 . 1999PNAS...96.2333G . free .
External links
Notes and References
- Web site: Endowed professorships for Gambhir and Relman. Stanford Report. 2 January 2013. June 2009.
- Web site: People.
- Web site: Leadership.
- Web site: Leadership.
- Web site: Leadership.
- Web site: Sanjiv Sam Gambhir, MD, PhD's Profile | Stanford Profiles. profiles.stanford.edu.
- Web site: And yet, you try. Stanford Medicine. 15 November 2016 . 2016-12-10.
- Web site: Sanjiv Sam Gambhir, MD, PhD's Profile | Stanford Profiles. profiles.stanford.edu.
- https://ektron.rsna.org/Sanjiv_Sam_Gambhir_MD_PhD.aspx
- Web site: Precision Health and Integrated Diagnostics. Precision Health and Integrated Diagnostics Center at Stanford.
- Web site: Sanjiv Sam Gambhir, MD, PhD, Receives 2018 Benedict Cassen Prize for Research in Molecular Imaging - SNMMI. www.snmmi.org.
- Web site: May 9, 2011 - The Dean's Newsletter - Stanford University School of Medicine.
- Web site: Medical Center People. news.stanford.edu. 23 January 2023 .
- Web site: 2004 News. Molecular Imaging Program at Stanford.
- http://www.snm.org/index.cfm?PageID=3190 Gambhir Receives SMI’s Achievement Award
- Web site: Doctors win $1.5 million awards for cancer research. © Stanford University. Stanford. California 94305 Copyright Complaints Trademark. Notice. November 3, 2004. Stanford University.
- Web site: Medical Center People. © Stanford University. Stanford. California 94305 Copyright Complaints Trademark. Notice. March 8, 2006. Stanford University.
- Web site: College of Fellows : AIMBE. https://web.archive.org/web/20131020032831/http://www.aimbe.org/members/college-of-fellows/. dead. October 20, 2013.
- Aebersold Award Presented to Gambhir. July 1, 2006. Journal of Nuclear Medicine. 47. 7. 26N. 16871693. jnm.snmjournals.org.
- Web site: Home. The American Society for Clinical Investigation.
- http://www.iom.edu/Global/Directory/Detail.aspx?id=0020003718 Sanjiv Gambhir – Institute of Medicine
- Web site: 2009 RSNA Outstanding Researcher.
- http://iasnm.us/HTML/news_awards.html- The Gopal Subramanian Lifetime Achievement Award
- Web site: SNM’s 2011 Georg Charles de Hevesy Nuclear Pioneer Award.
- Web site: AuntMinnie.com announces winners of 2014 Minnies awards for excellence in radiology. AuntMinnie.com.
- Web site: Distinguished Scientist Award for Distinguished Contributions to Nuclear Medicine. https://web.archive.org/web/20140517071729/http://www.wrsnm.org/meetings.htm. dead. May 17, 2014.
- Web site: Society of Asian American Scientists in Cancer Research Award. https://web.archive.org/web/20140409093100/http://www.indiawest.com/news/10599-eight-indian-american-scientists-honored-by-saascr.html. dead. April 9, 2014.
- Web site: American Association of Indian Scientists in Cancer Research Lifetime Achievement Award. https://web.archive.org/web/20140310035744/http://www.aacr.org/home/scientists/scientific-achievement-awards/lifetime-achievement-award.aspx. dead. March 10, 2014.
- Web site: American Association for the Advancement of Science (AAAS) Fellow Award.
- Web site: 2015 Taylor Prize Recipient | Robarts Research. www.robarts.ca.
- Web site: National Academy of Inventors. www.academyofinventors.org. 2017-01-05.
- Web site: AAAS - The World's Largest General Scientific Society . www.aaas.org. 2017-01-10.
- Web site: Benedict Cassen Prize for Research in Molecular Imaging. June 25, 2018.
- Web site: Institute of Electrical and Electronics Engineers (IEEE) Marie Sklodowska-Curie Award - IEEE Advancing Technology for Humanity. https://web.archive.org/web/20180831002417/https://www.ieee.org/content/dam/ieee-org/ieee/web/org/about/awards/recipients/awards_search.pdf. dead. August 31, 2018. Institute of Electrical and Electronics Engineers (IEEE) .